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How to Use Cream for Fertility

Written by
Dr. Vidhi Hareshbhai Talati
and medically reviewed by iCliniq medical review team.

Published on Apr 13, 2018 and last reviewed on May 29, 2019   -  4 min read



This article discusses the normal ovulation process, what are the available creams for improving fertility, and how it is to be used.

How to Use Cream for Fertility

How Does the Ovulation Process Occur?

When an ovum is released from any one of the ovaries, it comes inside the uterus (to become fertilized by the sperm). This phase is known as the luteal phase. At this time, the uterine lining becomes thick, and with lots of blood vessels to provide protection and nutrition to the fertilized egg in preparation for a possible pregnancy. If fertilization does not occur, this uterine lining starts to shed off and menstruation or period may start.

For conceiving a baby, ovulation is the necessary process which is well regulated by the female hormones progesterone and estrogen. There are many signs and symptoms associated with ovulation process. They are:

Some research shows that a woman may become more conscious of her looks and facial attractiveness during this time.

How to Know About Initiation of Ovulation?

There are many methods to calculate the ovulation time. The most reliable and easy way is to remember that ovulation starts approximately 14 days before the expected menstruation date.

What Is the Cream Available for Fertility?

Progesterone Creams: This is a hormonal cream mainly used for enhancing the process of fertility. Progesterone is a hormone which increases the basal temperature of the body. That is why it is also referred to as warm temperature hormone. This hormone is mainly used for manufacturing creams that are used to improve fertility. It is used in those patients who have low progesterone levels.

The most important function of this hormone is developing the uterus for pregnancy. When pregnancy presents, secretion of progesterone occurs for eight weeks. When pregnancy does not occur, secretion will become low and cause menstruation.

Progesterone cream makes the uterus healthy so that the fertilized egg can attach and survive, makes the vagina and cervix more accessible for the sperm to enter, prevents the rejection of fertilized egg, promotes the development of the fetus, and increases sexual desire, which ultimately enhances the pregnancy.

What Are the Indications for Using Progesterone Cream?

There are quite a few indications for using progesterone cream for pregnancy. Some of them are:

How to Use This Cream?

A person may start applying this cream after the ovulation process. If by mistake, the patient does begin to use the cream before the ovulation period, it will give an opposite effect. It restricts the fertility process rather than enhance fertility. Ovulation process is restricted when the person starts to apply the Progesterone cream before ovulation. As the hormone progesterone is a stimulator of menstruation, it may lead to miscarriage. High level of progesterone in the body is responsible for the initiation of menstruation. So, if it is used early, it is used to induce the menstruation rather than improve fertility.

Transdermal application over the skin is very beneficial. It is a fat-soluble protein. When it is applied over the skin, it is absorbed by the fat tissues beneath the skin. It is stored in the fat tissues, and then, it releases the hormone into the pelvic blood vessels. From the blood vessels, it is pumped to the heart, and from the heart, it goes to different parts of the body.

What is the Dosage?

The woman may apply this cream on the abdomen, face, inner thigh, upper neck, chest, breast, palms, and feet. But for better function, inner thigh or lower abdomen is preferred as it directly reaches the target tissue.

If it is used in premenopausal women, 16 to 25 mg per day is very beneficial when applied 14 days before menstruation date. It should be stopped on the day of menstruation or before periods.

It is most effective when it is applied over the inner thigh from the twelfth day of the cycle to the twenty-sixth day. It increases the formation of endometrial tissues within the uterus. It helps to make the uterus ready for the implanted fertilized egg.

Menopausal women can also use this for conceiving. Research shows that Progesterone cream will act as a stimulus for menses. They can take 15 mg, and it is to be taken for the first 25 days of the month, then take five or six days off and restart on the first of the month.

Some research shows that if women are dividing the dose and applying it across two times a day, it would be more beneficial rather than applying the whole dose once a day. So, there are many beneficial effects of the Progesterone cream for fertility. It is a non-surgical and cheap method for conceiving.

Loading Dose

This method is useful for those who have a severe deficiency of progesterone hormone. Deficiency of progesterone causes lack of ovulation. This woman becomes estrogen-dominant due to the reduction of progesterone store in the body. This type of woman is usually thin and has little fat tissues in her body. In this woman, a higher dose will be recommended, approx 40 mg, two times per day to start ovulation for two months. After that, the dose will be decreased to the standard dose.

What Is the Complication of This Cream?

Do not apply too much over the target area, or it will cause hormonal imbalance in the body. The effect of the cream starts within a few seconds of application. When the woman begins to apply a hormonal cream, its effects last for a few hours after use. But later on, problems may start. Splitting of the dosage may decrease this problem. Splitting it to two times a day is a better option than applying the entire dose all at once.

Topical application of Progesterone has negligible adverse effects on the body. The cream also contains the perfect amount which does not harm the bodily functions. Gel and cream both are available and equally effective.

A Word of Caution

When the person is applying this cream over the skin, the skin will absorb the cream as well as the hormone in the fat tissue. Fat tissue stores this hormone. Initially, the cream provides beneficial effects because the storage of the hormone is very low, but as time goes on, peak saturation of fat tissue may be achieved. Progesterone is a highly fat-soluble hormone. After many applications, the fat tissue will become saturated with the hormone, and it does not provide any beneficial effects.

Sometimes, over-saturation may produce harmful effects. This condition is referred to as dermal fatigue. After reaching the saturation point, progesterone may hamper the adrenal hormone, cortisol, and testosterone. That is why progesterone cream is to be used with caution.

For more information consult an infertility treatment specialist online -->


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Last reviewed at:
29 May 2019  -  4 min read


Dr. Vidhi Hareshbhai Talati

Dr. Vidhi Hareshbhai Talati

Masters in Physiotherapy

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