Published on Apr 27, 2017 and last reviewed on Feb 19, 2020 - 7 min read
Progesterone cream is a natural hormone replacement therapy. Read the article to know the indications, contraindications, dosage, and complications of using it.
Progesterone is produced by ovary approximately 20 to 30 mg daily. Adrenal gland also produces some amount of progesterone. It is mainly produced during the last phase of the menstrual cycle. During each year, the amount of progesterone production is falling and by the fifth or sixth decade of the life it gets totally diminished. This mechanism is known as menopause. Menopause is due to the fall in the level of progesterone in 90% of women. This is the reason for the end of menstrual cycle in women during their fifth or sixth decade.
When an ovum is released from any one of the ovary, it comes inside the uterus to become fertilized with sperm. This phase is known as the luteal phase. At this time, the uterine lining becomes thick with lots of blood vessels to provide protection and nutrition to the fertilized egg. If fertilization does not occur, this uterine lining starts to shed off and menstruation or the period may starts. For conceiving a baby, ovulation is the necessary process which is well regulated by progesterone and estrogen hormone. There are many signs and symptoms associated with ovulation process such as a slight increase in the temperature of the body, white mucus secretion from the cervix or vagina and also some pain in the lower abdominal region. Many women feel that they have high peak of sexual desire during these days. Some researches show that woman may become more conscious about their look and facial attractiveness during this time.
There are many methods available for calculating the time of ovulation. The most reliable and easy method is that ovulation starts on the 14th day from menstruation date.
There are many beneficial effects of the progesterone for fertility. It is a cheap non-surgical method for conceiving.
Deficiency of progesterone causes lack of ovulation. This woman becomes an estrogen dominant person due to reduction of progesterone store in her body. This type of woman is usually thin who has little fatty tissue in her body. Progesterone cream makes uterus healthy where fertilized egg attaches and survives, makes vagina and cervix more accessible for entering of sperm into uterus, prevents rejection of fertilized egg, promotes development of fetus, increases sexual desire, etc., which ultimately enhances the pregnancy.
Artificial progesterone, which is made in the laboratory has many complications. Complications associated with synthetic progesterone are brain stroke, abnormal menstrual flow, cancer, nausea, retention of fluid in tissues of peripheral extremities, depression and increases the possibilities for heart attack. That is why the natural progesterone cream has become more popular nowadays.
Natural progesterone is best obtained from the plants like wild yams and soybeans. The complications associated with synthetic progesterone can be minimized with the intake of natural progesterone. Instant relief is achieved by topical progesterone cream for painful abdominal cramps. It is also used for the prevention of threatened abortion or miscarriage.
The normal mechanism for this hormone is that, it is synthesized and secreted by ovary itself into the vessels of the pelvis which in turn supply different parts of the body through the pumping action of the heart.
If a person takes this orally, it will cause severe acid formation in the stomach. As a result, the effect of progesterone will get damaged by more acid secretion. This hormone further enters into liver, will get metabolized and damaged. These hormones are screened by the liver and some of the damaged ones will get eliminated through urine. So, through oral preparation only 15% to 20% of total quantity will reach the target area. If a patient wants to take it orally, she has to take more than 500% of actual amount, but this amount increases acid secretion in the stomach. Furthermore, the liver may produce different varieties of metabolites. Progesterone combines with these metabolites and causes allergic reactions. Many complications may appear due to this reaction. That is why progesterone cream is widely used than oral intake.
There are many indications for using progesterone cream for pregnancy such as,
Some researches show that if women divide the dosage and apply it two times in a day, then it would be more beneficial rather than applying the entire dose once in a day. When women start to apply hormonal cream, its effect will last for 6 hours after application. Splitting of dosage may help a lot because splitting will allow 12 hours of efficacy.
To hear more about natural progesterone cream, consult an obstetrician and gynaecologist online --> https://www.icliniq.com/ask-a-doctor-online/obstetrician-and-gynaecologist
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