Reproductive(Fertility) Health

Progesterone Cream - Time of Ovulation, Beneficial Effects, Dosage

Written by
Dr. Vidhi Hareshbhai Talati
and medically reviewed by iCliniq medical review team.

Published on Apr 27, 2017 and last reviewed on Feb 19, 2020   -  7 min read



Progesterone cream is a natural hormone replacement therapy. Read the article to know the indications, contraindications, dosage, and complications of using it.

Progesterone Cream - Time of Ovulation, Beneficial Effects, Dosage

Progesterone is produced by ovary approximately 20 to 30 mg daily. Adrenal gland also produces some amount of progesterone. It is mainly produced during the last phase of the menstrual cycle. During each year, the amount of progesterone production is falling and by the fifth or sixth decade of the life it gets totally diminished. This mechanism is known as menopause. Menopause is due to the fall in the level of progesterone in 90% of women. This is the reason for the end of menstrual cycle in women during their fifth or sixth decade.


When an ovum is released from any one of the ovary, it comes inside the uterus to become fertilized with sperm. This phase is known as the luteal phase. At this time, the uterine lining becomes thick with lots of blood vessels to provide protection and nutrition to the fertilized egg. If fertilization does not occur, this uterine lining starts to shed off and menstruation or the period may starts. For conceiving a baby, ovulation is the necessary process which is well regulated by progesterone and estrogen hormone. There are many signs and symptoms associated with ovulation process such as a slight increase in the temperature of the body, white mucus secretion from the cervix or vagina and also some pain in the lower abdominal region. Many women feel that they have high peak of sexual desire during these days. Some researches show that woman may become more conscious about their look and facial attractiveness during this time.

Time of Ovulation

There are many methods available for calculating the time of ovulation. The most reliable and easy method is that ovulation starts on the 14th day from menstruation date.

Role Of Progesterone

  • Progesterone is mainly used for enhancing the process of fertility. Most important functions of this hormone are developing uterus for pregnancy.
  • This hormone increases the basal temperature of the body and so, it is also referred as a warm temperature hormone.
  • When pregnancy presents, secretion of the progesterone occurs for 8 weeks. When pregnancy does not occur, secretion will become low and cause menstruation.
  • Possibility of breast cancer is also minimized with the help of progesterone hormone because it helps to balance the larger quantity of the estrogen hormone. High concentration of estrogen in the body is the main cause of the breast cancer.
  • It also acts as a mediator in our body for producing other hormones such as adrenal, estrogen and testosterone.
  • This hormone is mainly used for manufacturing of creams for increasing fertility process. It is used in those patients who have low levels of progesterone.

What Are the Beneficial Effects of the Progesterone?

There are many beneficial effects of the progesterone for fertility. It is a cheap non-surgical method for conceiving.

  1. It reduces and protects the risk of breast cancer and tumor – as above mentioned.
  2. It prevents cramps during the premenstrual period.
  3. It prevents the accumulation of the fat tissue in the hip area.
  4. It increases the formation of endometrial tissue within the uterus.
  5. It enhances the action of thyroid hormone.
  6. Abnormal blood coagulation or blood clotting is best prevented with progesterone cream.
  7. It helps to increase the sexual desire.
  8. It also helps to balance the level of sugar in blood.
  9. It also enhances the oxygenation of each and every tissue of the body and helps to provide energy.
  10. It also works as a preventive hormone for reduction of the risk of endometrial organ cancer.
  11. Bone strength is also increased by progesterone cream.

Progesterone Cream

Deficiency of progesterone causes lack of ovulation. This woman becomes an estrogen dominant person due to reduction of progesterone store in her body. This type of woman is usually thin who has little fatty tissue in her body. Progesterone cream makes uterus healthy where fertilized egg attaches and survives, makes vagina and cervix more accessible for entering of sperm into uterus, prevents rejection of fertilized egg, promotes development of fetus, increases sexual desire, etc., which ultimately enhances the pregnancy.

Natural Versus Artificial Progesterone Cream

Artificial progesterone, which is made in the laboratory has many complications. Complications associated with synthetic progesterone are brain stroke, abnormal menstrual flow, cancer, nausea, retention of fluid in tissues of peripheral extremities, depression and increases the possibilities for heart attack. That is why the natural progesterone cream has become more popular nowadays.

Natural progesterone is best obtained from the plants like wild yams and soybeans. The complications associated with synthetic progesterone can be minimized with the intake of natural progesterone. Instant relief is achieved by topical progesterone cream for painful abdominal cramps. It is also used for the prevention of threatened abortion or miscarriage.

The normal mechanism for this hormone is that, it is synthesized and secreted by ovary itself into the vessels of the pelvis which in turn supply different parts of the body through the pumping action of the heart.

If a person takes this orally, it will cause severe acid formation in the stomach. As a result, the effect of progesterone will get damaged by more acid secretion. This hormone further enters into liver, will get metabolized and damaged. These hormones are screened by the liver and some of the damaged ones will get eliminated through urine. So, through oral preparation only 15% to 20% of total quantity will reach the target area. If a patient wants to take it orally, she has to take more than 500% of actual amount, but this amount increases acid secretion in the stomach. Furthermore, the liver may produce different varieties of metabolites. Progesterone combines with these metabolites and causes allergic reactions. Many complications may appear due to this reaction. That is why progesterone cream is widely used than oral intake.

Indications for Using Progesterone Cream

There are many indications for using progesterone cream for pregnancy such as,

  1. Multiple and recurrent miscarriage.
  2. Absence of menstruation.
  3. PCOS (polycystic ovarian syndrome) - multiple cysts in ovary.
  4. Loss of sexual desire.
  5. Obesity, which restricts the fertility.
  6. Vaginal and cervix dryness.
  7. Severe deficiency of progesterone hormone.

How to Use Progesterone Cream?

  • If a person wants to get the maximum effect of this cream, then choose the route that directly delivers this hormone to ovary.
  • The cream has an appropriate quantity of hormone with negligible side effects. Progesterone is available in the form of base with gel or cream. Both are equally beneficial.
  • Transdermal application over the skin is very beneficial. Through this way, gastrointestinal complication is bypassed. It can be applied once or twice a day.
  • When applied over the skin, it gets absorbed by the fat tissues beneath the skin. It is a fat soluble protein. Then the fat tissue will release the hormone into pelvic vessels. Through blood vessels it will reach the heart and gets supplied to different parts of the body.
  • A woman may apply this cream on the abdomen, face, inner thigh, upper neck, chest, breast, palms and feet. For better function, inner thigh or lower abdomen is the best location for application of cream. This is the area where fat tissues are more and another advantage is that the uterus and ovary are near to it. It may also be applied over the surface of the vagina so that the hormone directly enters into pelvic vessels and from there it circulates in body through heart same as above stated natural circulation.


  • For premenopausal women - 15 to 24 mg per day for 14 days before expected period is beneficial and should be stopped the day before periods. It means that women should start the cream from the 12th day of the period and stop at 26th day. Withdrawal of the cream will cause decrease in the level of the progesterone and it will become a stimulus for menses. That time menstrual cramps on the lower abdominal area may reduce.
  • For menopausal women - 15 mg per day for the first 25 days of the month, then stop for 5 or 6 days and then restart on the first of the next month.
  • In case of an estrogen dominant person, higher dose will be recommended approximately 40 mg twice a day for two months to start ovulation. After that, the dose will decrease and will become normal.

Some researches show that if women divide the dosage and apply it two times in a day, then it would be more beneficial rather than applying the entire dose once in a day. When women start to apply hormonal cream, its effect will last for 6 hours after application. Splitting of dosage may help a lot because splitting will allow 12 hours of efficacy.

Complications of Progesterone Cream

  • One should not apply too much over the target area as it will cause hormonal imbalance in the body. Effect of cream does start within few seconds of application. When women start to apply hormonal cream, its effect last for few hours after application, later on problems may start. Splitting of dosage may decrease this problem. Two times in a day is a better option.
  • When a person is applying this cream over the skin, the skin will absorb the cream as well as a hormone in fat tissue. Fat tissue stores this hormone. Initially, cream provides beneficial effects because storage of hormone is very low, but as time goes on, peak saturation of fat tissue may be achieved. Progesterone is highly a fat soluble hormone. After many applications, the fat tissue will become saturated with the hormone and it does not provide any beneficial effects. Sometimes, over saturation may produce harmful effects. This condition is referred as dermal fatigue. After reaching the saturation point, progesterone may hamper the adrenal hormone, cortisol and testosterone. So, progesterone cream has to be used with caution.
  • Natural progesterone cream disturbs the normal cycle of menstruation. A person should start this cream after ovulation process. If, by mistake, the patient does start to use cream before ovulation period, it will give opposite effect. It restricts the fertility process rather than enhancing it. Because, progesterone is a stimulator of the menstruation and it may lead to miscarriage. The high level of the progesterone in the body is responsible for initiation of the menstruation. So, if it is early, it is used to induce the menstruation rather than improving fertility.

To hear more about natural progesterone cream, consult an obstetrician and gynaecologist online -->

Last reviewed at:
19 Feb 2020  -  7 min read




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