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Progesterone Cream - Time of Ovulation, Beneficial Effects, Dosage

Written by
Dr. Vidhi Hareshbhai Talati
and medically reviewed by iCliniq medical review team.

Published on Apr 27, 2017 and last reviewed on Feb 19, 2020   -  7 min read



Progesterone cream is a natural hormone replacement therapy. Read the article to know the indications, contraindications, dosage, and complications of using it.

Progesterone Cream - Time of Ovulation, Beneficial Effects, Dosage

Progesterone is produced by ovary approximately 20 to 30 mg daily. Adrenal gland also produces some amount of progesterone. It is mainly produced during the last phase of the menstrual cycle. During each year, the amount of progesterone production is falling and by the fifth or sixth decade of the life it gets totally diminished. This mechanism is known as menopause. Menopause is due to the fall in the level of progesterone in 90% of women. This is the reason for the end of menstrual cycle in women during their fifth or sixth decade.


When an ovum is released from any one of the ovary, it comes inside the uterus to become fertilized with sperm. This phase is known as the luteal phase. At this time, the uterine lining becomes thick with lots of blood vessels to provide protection and nutrition to the fertilized egg. If fertilization does not occur, this uterine lining starts to shed off and menstruation or the period may starts. For conceiving a baby, ovulation is the necessary process which is well regulated by progesterone and estrogen hormone. There are many signs and symptoms associated with ovulation process such as a slight increase in the temperature of the body, white mucus secretion from the cervix or vagina and also some pain in the lower abdominal region. Many women feel that they have high peak of sexual desire during these days. Some researches show that woman may become more conscious about their look and facial attractiveness during this time.

Time of Ovulation

There are many methods available for calculating the time of ovulation. The most reliable and easy method is that ovulation starts on the 14th day from menstruation date.

Role Of Progesterone

What Are the Beneficial Effects of the Progesterone?

There are many beneficial effects of the progesterone for fertility. It is a cheap non-surgical method for conceiving.

  1. It reduces and protects the risk of breast cancer and tumor – as above mentioned.
  2. It prevents cramps during the premenstrual period.
  3. It prevents the accumulation of the fat tissue in the hip area.
  4. It increases the formation of endometrial tissue within the uterus.
  5. It enhances the action of thyroid hormone.
  6. Abnormal blood coagulation or blood clotting is best prevented with progesterone cream.
  7. It helps to increase the sexual desire.
  8. It also helps to balance the level of sugar in blood.
  9. It also enhances the oxygenation of each and every tissue of the body and helps to provide energy.
  10. It also works as a preventive hormone for reduction of the risk of endometrial organ cancer.
  11. Bone strength is also increased by progesterone cream.

Progesterone Cream

Deficiency of progesterone causes lack of ovulation. This woman becomes an estrogen dominant person due to reduction of progesterone store in her body. This type of woman is usually thin who has little fatty tissue in her body. Progesterone cream makes uterus healthy where fertilized egg attaches and survives, makes vagina and cervix more accessible for entering of sperm into uterus, prevents rejection of fertilized egg, promotes development of fetus, increases sexual desire, etc., which ultimately enhances the pregnancy.

Natural Versus Artificial Progesterone Cream

Artificial progesterone, which is made in the laboratory has many complications. Complications associated with synthetic progesterone are brain stroke, abnormal menstrual flow, cancer, nausea, retention of fluid in tissues of peripheral extremities, depression and increases the possibilities for heart attack. That is why the natural progesterone cream has become more popular nowadays.

Natural progesterone is best obtained from the plants like wild yams and soybeans. The complications associated with synthetic progesterone can be minimized with the intake of natural progesterone. Instant relief is achieved by topical progesterone cream for painful abdominal cramps. It is also used for the prevention of threatened abortion or miscarriage.

The normal mechanism for this hormone is that, it is synthesized and secreted by ovary itself into the vessels of the pelvis which in turn supply different parts of the body through the pumping action of the heart.

If a person takes this orally, it will cause severe acid formation in the stomach. As a result, the effect of progesterone will get damaged by more acid secretion. This hormone further enters into liver, will get metabolized and damaged. These hormones are screened by the liver and some of the damaged ones will get eliminated through urine. So, through oral preparation only 15% to 20% of total quantity will reach the target area. If a patient wants to take it orally, she has to take more than 500% of actual amount, but this amount increases acid secretion in the stomach. Furthermore, the liver may produce different varieties of metabolites. Progesterone combines with these metabolites and causes allergic reactions. Many complications may appear due to this reaction. That is why progesterone cream is widely used than oral intake.

Indications for Using Progesterone Cream

There are many indications for using progesterone cream for pregnancy such as,

  1. Multiple and recurrent miscarriage.
  2. Absence of menstruation.
  3. PCOS (polycystic ovarian syndrome) - multiple cysts in ovary.
  4. Loss of sexual desire.
  5. Obesity, which restricts the fertility.
  6. Vaginal and cervix dryness.
  7. Severe deficiency of progesterone hormone.

How to Use Progesterone Cream?


Some researches show that if women divide the dosage and apply it two times in a day, then it would be more beneficial rather than applying the entire dose once in a day. When women start to apply hormonal cream, its effect will last for 6 hours after application. Splitting of dosage may help a lot because splitting will allow 12 hours of efficacy.

Complications of Progesterone Cream

To hear more about natural progesterone cream, consult an obstetrician and gynaecologist online -->


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Frequently Asked Questions


What Is the Use of Progesterone Cream?

Progesterone cream is one of the treatments used in postmenopausal women. It is a form of hormone replacement therapy (HRT). The primary purpose of using progesterone creams is to relieve menopausal symptoms such as hot flushes, skin aging signs, and it also prevents bone loss that would lead to osteoporosis.


Do Progesterone Creams Work More Effectively When Compared to Oral Progesterone?

There is not much research so far about the advantages and disadvantages of progesterone cream. Most studies suggest that progesterone cream does not work very well when applied topically over the skin. Progesterone, to be effective, needs to be administered into the bloodstream. The major disadvantage of progesterone cream is the least absorption into the bloodstream.


What Are the Side Effects of Progesterone Cream?

The side effects caused by using progesterone cream may vary widely based on the product you use. The most common side effects experienced by women is sensitivity to the active ingredient in the product. Other associated symptoms are a moderate increase in weight, drowsiness, nausea, headaches, and breast pain (mastalgia).


When Should a Woman Take Progesterone Cream During Her Menstrual Period?

It would be best if you started taking your progesterone creams for a period between your date of ovulation (day 14 of the menstrual cycle) until two or three days before the onset of your menses. Progesterone cream is effective in inducing fertility only when it is used in this particular period.


What Is the Natural Function of Progesterone in a Woman?

The natural function of progesterone is to prepare the endometrium for pregnancy after ovulation has occurred. It triggers the endometrial lining of the uterus to thicken. This is to enable the implantation of a fertilized egg. Once the egg has been implanted, it prohibits the occurrence of muscle contractions in the uterus, which might expel the egg.


What Are the Signs for Low Progesterone Levels?

When a woman has low progesterone levels, she might experience symptoms such as.
- Menstrual cycle abnormality.
- Infertility.
- Headaches that include migraine.
- Mood swings.
- Hot Flashes.
- Weight Gain.
- Fibroids
- Endometriosis.


What Are the Most Common Uses of Progesterone Creams?

The most common use of progesterone is to treat irregular menstrual periods. It is also used in the treatment of uterine bleeding and the symptoms of premenstrual syndrome (PMS).


What Is the Safe Amount of Progesterone Cream for Daily Usage?

When a woman is affected by postmenopausal symptoms such as hot flashes and bone deformities, it is usually safe to use 20 mg of progesterone cream daily. It can be used in sites like the breasts, thighs, and upper arms.


Does Progesterone Cream Cause Weight Gain?

One of the most common side effects experienced by progesterone cream was weight gain in recent studies among women. Progesterone stimulates the thyroid gland to increase the basal body temperature and metabolism of the patient.


Who Can Benefit From Using Progesterone Cream?

Progesterone cream plays a vital part in the process of hormone replacement in postmenopausal women. It relieves symptoms such as the hot flushes. It can also be used to increase the sexual drive in women after menopause. It also increases bone density in women.


Does Progesterone Cream Treat Facial Wrinkles?

The progesterone helps the skin to grow thicker and become more elastic. This reduces the incidence of creases or wrinkles in women in their perimenopausal and postmenopausal periods. The cream can be applied twice a day in areas like the forehead, perioral area, and areas around the eye.


Why Should I Balance My Estrogen and Progesterone Naturally?

High levels of estrogen and low levels of blood progesterone levels can lead to painful periods. So, balancing these hormones on equal levels will help in treating period cramps. This can be achieved by adding flax seeds and sesame to the diet. Avoiding unnecessary stress by practicing yoga and meditation will be helpful.


What Are the Psychological Benefits of Progesterone Cream?

Progesterone has been used as a primary mode of treatment in women who suffer from postpartum depression. The reason behind this is that it elevates mood and acts as a natural antidepressant. Also, by relieving menopausal symptoms such as hot flushes, it works as a happy pill.


What Vitamin Plays a Vital Role in Increasing Progesterone Levels?

Vitamin B6 is also known as pyridoxine. Women who intake high dietary content of vitamin B6 such as fish, peanuts, bananas, oats, and wheat grams have more progesterone than other women. Women who have high vitamin B6 content are noted to have lesser miscarriages. For women who are infertile, adding vitamin B6 can improve their rate of fertility.


What Is the Right Method to Use Natural Progesterone Cream?

It is indicated that women who suffer from perimenopausal symptoms use a one-quarter teaspoon of cream twice a day. The cream should be started exactly two weeks before the onset of the menses. The usage of progesterone cream should be stopped two or three days before the beginning of the period.


After How Many Days Can I Expect My Progesterone Cream to Work?

Oral progesterone is more effective when compared to topical progesterone creams. This is because it takes two to three months to start working. At the same time, progesterone cream takes half an hour to one hour to start its work. Progesterone cream should always be used to avoid sudden hormonal imbalance.


Can You Use Progesterone Cream for Fertility?

Progesterone creams have been used to increase fertility in a woman. This cream should be used only when an obstetrician prescribes it. It should be started on the day of ovulation until the day where the periods begin. The date of ovulation in a menstrual cycle is day 14. The progesterone cream should be applied on the neck, forearm, and inner thigh regions to be very effective.


What Is the Effect of Folic Acid on Progesterone?

Many studies have found that a diet that is rich in synthetic folate supplements is very frequently associated with increased progesterone levels in females. This increased progesterone levels lowered the risk of infrequent anovulation by several times. Research evidence also strongly suggests administering dietary folate and folic acid supplement when a woman is planning to have a baby.


Can Progesterone Cream Cause Ovarian Cancer?

Many doctors opposed hormonal replacement therapy in menopausal women. It is mainly due to its severe side effects. Progesterone replacement therapy through any route increases the risk of ovarian cancer. In addition to ovarian cancer, it can also cause cardiac problems, coagulation problems, endometriosis, and uterine fibroids.


Does Natural Progesterone Help With Weight Loss?

Natural progesterone has tremendous effects on weight loss. But on the other hand, progesterone cream is found to cause weight gain. Natural progesterone causes weight loss by enhancing thyroid metabolism, lowering insulin levels, etc.


Does Progesterone Cream Treat PCOS and Infertility?

Yes, when a woman properly uses progesterone cream from her day of ovulation until her onset of periods, chances of getting pregnant increase. Administering progesterone as oral contraceptive pills also regularise the menstrual cycle. This is chiefly because of the effect of progesterone on sleep, mood, and natural fertility.


Can I Reverse the Effects of Progesterone Cream at Home?

It is usually not advisable to choose home remedies when you use excess progesterone creams. It could cause serious side effects. You need to consult the doctor. Based on the amount of excess cream you have used, the doctor will choose his or her management plan and treat you accordingly. Never, self medicate yourself with any medicines.


Is It Normal to Have Breast Pain Before My Periods?

During the luteal phase, the woman's breast naturally gets a little dense and modular. This is quite common for three to four days before the onset of menses. You need not worry about it because the pain naturally resolves.

Last reviewed at:
19 Feb 2020  -  7 min read


Dr. Vidhi Hareshbhai Talati

Dr. Vidhi Hareshbhai Talati

Masters in Physiotherapy

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