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Transepidermal Water Loss - An Overview

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Transepidermal water loss is something important to be taken into consideration in skincare. Read the article to know about transepidermal water loss.

Medically reviewed by

Dr. Dhepe Snehal Madhav

Published At November 16, 2022
Reviewed AtFebruary 28, 2023

Introduction

The skin comprises three layers - the superficial epidermis, the middle layer of the dermis, and the deepest hypodermal layer. When water passes through these layers and reaches the epidermis, they evaporate from them. This is known as transepidermal water loss. However, this is a naturally occurring process where an average individual loses 300 to 400 ml of water through the skin. Certain factors aggravate the transepidermal water loss by affecting the skin's barrier function.

What Is the Mechanism Behind Transepidermal Water Loss?

The superficial epidermal layer of the skin has sublayers such as stratum basale, stratum spinosum, stratum granulosum, and stratum corneum. A water gradient exists among these layers. The water content of the stratum corneum is lower than that of the other layers, so passive diffusion of water occurs from the innermost layers towards the superficial stratum corneum.

Most water obtained by passive diffusion is eliminated as vapor, and the remaining fraction is retained in the stratum corneum. The water eliminated as vapor is called transepidermal water loss. This is a natural process. A perfectly functioning stratum corneum. Controls the water gradient between these layers. But if there is a chemical or chemical trauma to the layer, it may reflect some adverse effects on the skin.

What Causes Transepidermal Water Loss?

  • Trauma to the skin, such as eczema or sunburn.

  • Impaired metabolism.

  • Impaired sweat gland function.

  • Over-drying skin care products.

  • Over-exfoliating with harsh soaps.

  • Chlorine in the swimming pool.

  • Low humid climates.

  • Impaired skin barrier

  • Aging skin.

How Can Transepidermal Water Loss Be Measured?

Generally, the skin's barrier functions are assessed by measuring the transepidermal water loss. They can be measured using devices such as an open chamber, airless chamber, and condenser chamber device. The transepidermal water loss has to be measured under controlled conditions as they are more sensitive and can be affected by environmental humidity, temperature, and airflow.

How Does Transepidermal Water Loss Affect the Skin?

Transepidermal water loss, although a natural process, allows the escape of moisture from the skin and results in unwanted skin conditions.

The signs noticed in an individual with transepidermal water loss include,

  • Irritation: Since the skin barrier is damaged, irritation occurs.

  • Flaking: The superficial layer of the skin dries and gets peeled off in flakes.

  • Itching: The skin cracks cause an itchy feeling.

  • Tightness: The skin cells are dehydrated, so they condense together and give a tight feeling.

  • Fine Lines and Wrinkles: The excess loss of water content can also lead to the formation of fine lines and wrinkles on the skin.

How to Prevent Transepidermal Water Loss?

The best way to prevent transepidermal water loss is to enhance the skin's barrier function. Healthy skin is good at trapping moisture and natural oils and at combating the irritants trying to enter the skin. Certain practices can enhance skin health and prevent transepidermal water loss.

They are,

  • Gentle Cleanse Your Skin: The strong skin barrier can get weakened if there is a practice of over-cleansing with products containing strong ingredients. Cleanse your skin twice a day with a gentle cleanser which helps to maintain the skin barrier without damage.

  • Use Hydrating Serum: By delivering hydrating ingredients to your skin through serums, transepidermal water loss can be minimized. Hydrating serums containing hyaluronic acid work well at drawing moisture into the skin and retaining the moisture in it. It also contains vitamin B5, which treats dry skin.

  • Use Moisturizers Regularly: Moisturizers should be applied daily after the cleanser and serum to enhance the skin's barrier function. Applying moisturizers immediately after a shower is the best way to trap moisture. It is recommended to use moisturizers daily and not when you feel your skin dry.

  • Use Humidifiers: Low humidity in the environment leads to the aggravation of transepidermal water loss. So use a humidifier to

  • Use Hand Creams: The skin barrier in your hands can easily get damaged due to continuous exposure to soaps and detergents. So it is recommended to use hand cream for moisturizing the hands and prevent skin damage due to impaired barrier function.

  • Skin Hydrating During Bath: Take a bath for only 5 to 10 minutes and not more to prevent moisture loss and natural oils from the skin. Take a bath using warm water, not hot water, followed by applying an occlusive moisturizer to lock the moisture. For hydrating your face, place a wet cloth on the face.

  • Do Not Over-Exfoliate: As a general rule, avoid over-exfoliation of the skin, as it strips away the natural oils and water content in the skin. This leads to an impaired skin barrier function leading to excessive transepidermal water loss. Avoid using exfoliants containing retinol and alpha hydroxy acids as they can worsen and aggravate transepidermal water loss.

What Are the Ingredients That Avoid Transepidermal Water Loss?

It is essential to look for the key ingredients that keep your skin hydrated and protect your skin barrier.

Some of those ingredients are as follows.

  • Ceramides: These are natural oils present in the skin. The 50% composition of the skin contains ceramides which play a vital role in maintaining the skin barrier function. So adding ceramides to your skincare routine would help maintain your skin health.

  • Hyaluronic Acid: It is a humectant that traps moisture in the skin. Use cleansers, serums, and moisturizers containing hyaluronic acid for the best-hydrated skin.

  • Niacinamide: It is an active form of vitamin B3 that improves the skin's ability to retain moisture.

  • Glycerin: Use moisturizers and cleansers containing glycerin as they are good at trapping the moisture in the skin and allowing the other ingredients of the products to enter the skin for the best results.

Conclusion

A variety of unpleasant skin conditions can result due to transepidermal water loss. To encounter those skin conditions, it is good to use skincare products that keep your skin moisturized all the time and do not cause any adverse effects. However, the results may vary among individuals; consistency and regularity of using the products may help you achieve the best results.

Frequently Asked Questions

1.

How to Transepidermal Water Loss?

Transepidermal water loss is the amount that diffuses across the area of the stratum corneum of skin in a unit of time. This amount of water that gets diffused from the skin is measured by using a probe that is in contact with the skin's surface and contains sensors that help to detect the changes in water vapor density.

2.

Is Transepidermal Water Loss the Same as Sweating?

Transepidermal water loss is a form of water loss where the sweat glands are not involved, while sweat glands are involved in water loss in sweating. Transepidermal water loss is considered essential from the skin's surface, a passive insensible process of losing water.

3.

What Does Tewl Measure in Skin?

Transepidermal water loss is measured using a probe containing sensors to detect changes in the vapor density at the skin surface when compared to a point a little away from the skin. During this procedure, the water is lost from the skin's stratum corneum, and the humidity next to the surface rises above the ambient humidity level.

4.

What Does Tewl Look Like?

 
When transepidermal water loss occurs, a person can notice a few indicators, such as dry skin, which includes flaking, roughness, and increased visibility of fine lines. A person may feel discomfort, tightness, and shrunken skin, which are signs of excessive transepidermal water loss. Skin conditions such as eczema, dermatitis, and rosacea cause transepidermal water loss.

5.

How Do Dermatologists Fix Dehydrated Skin?

 
The dermatologists recommended moisturizers, which include active ingredients such as ceramides, lipids, hyaluronic acids, copper peptides, and oatmeal, which help steer clear products that have fragrance. The moisturizers help to relieve the skin from tightness, make the skin soft, and remove flakes and scales.

6.

How to Reset Skin Barriers?

 
The skin barrier can be repaired by simplifying the skin care regimen, using skin products with suitable pH, and using a moisturizer that contains ceramides, a humectant like hyaluronic acid. This helps skin from dryness and nourishes the skin.

7.

Does Hyaluronic Acid Prevent Tewl?

Humectants such as glycerine and hyaluronic acid help to prevent transepidermal water loss. These humectants withdraw water from the environment into the skin. The other skin products that help in transepidermal water loss include occlusives and emollients.

8.

What Effect Does a Higher Tewl in Dark Skin Have?

Few studies show that darker-skinned people have higher levels of transepidermal water loss than fair-complexion people. The exact reason for this is due to the variable blood vessel reactivity , decreased skin surface pH, and large-sized mast cell granules when compared to fair complexion people.

9.

How Much Water Is Lost Through Skin?

On average, humans will lose 300 - 450 ml 0f water loss through diffusion and with approximately the same amount through the respiratory tract, which is around 350ml.  The combined total is around 30-50 percent of daily water loss depending on average two-liter water intake .800-2000 ml is through urine which is approximately considered in 24 hours. Extrarenal water loss can occur based on age and other underlying factors.

10.

Does Transepidermal Water Loss Cause Aging?

TWEL loss which is called transepidermal water loss occurs when water from the surface of the skin to the air evaporates into the air. TWEL can cause various skin conditions not limited to wrinkles and thin lines on the face. The dehydration caused due to TWEL speeds up the process of aging. TWEL can be reversed by using various skin products that include occlusives, humectants, etc.,

11.

How Does Skin Prevent Fluid Loss?

Skin acts as a barrier and prevents fluid loss. The skin's outer surface acts as a barrier called stratum corneum which helps prevent epidermal water loss. Few skin products such as emollients, humectants, and occlusives prevent fluid loss.

12.

Does Skin Protect Against Water Loss?

 
The skin's outer surface, called the stratum corneum, acts as a barrier and protects the skin from water loss. This can be prevented by various moisturizers that contain ceramides, a humectant like hyaluronic acid. Epidermal water loss is caused mainly by various skin conditions such as s eczema, dermatitis, and rosacea.

13.

Which Layer of Skin Prevents TEWL?

The skin's outer surface, called the stratum corneum, acts as a barrier and protects the skin from water loss. This can be prevented by various moisturizers that contain ceramides, a humectant like hyaluronic acid. Epidermal water loss is caused mainly by various skin conditions such as s eczema, dermatitis, and rosacea.

14.

Does Glycerin Maintain TEWL?

Glycerin not only helps moisturize the skin by increasing the lipid layer but also helps in decreasing transepidermal water loss. Few studies have shown that the glycerol applied under normal conditions has decreased the flux of water loss from the skin.
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Dr. Dhepe Snehal Madhav
Dr. Dhepe Snehal Madhav

Venereology

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