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Neonatal cholestasis results from too much conjugated bilirubin in the blood of newborns, which is called hyperbilirubinemia. This results from diminished bile formation or excretion, which is caused mainly due to biliary atresia. Biliary atresia is the obstruction of the bile ducts. Neonatal cholestasis becomes apparent after the first couple of months of life as the infant develop jaundice and dark urine. The causes of neonatal cholestasis can be infectious (herpes simplex virus, cytomegalovirus, rubella), gestational autoimmune liver disease, genetic conditions (cystic fibrosis, Alagille syndrome), and idiopathic neonatal hepatitis syndrome.