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Joint pain or stiffness can be debilitating and a challenge to treat. Chronic joint pain can affect the emotional and physical well-being of an individual. To reduce pain and discomfort, medicines are directly injected into the affected joint. Corticosteroid is the most common medication given as intra-articular injections. Some of the other less commonly injected drugs are Infliximab, Hyaluronic acid, Botulinum neurotoxin, and platelet-rich plasma (PRP). Intra-articular injections help manage pain and inflammation associated with osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. The contraindications for intra-articular injections are bacteremia, sepsis, intra-articular infections, and hypersensitivity to steroid injections.