I have had a positive ANA for at least 12 years with no other positive tests for autoimmune disease. My other symptoms are fatigue and some joint pain in hands and knees. Recently, I had a positive ANA of 1:640 speckled pattern with a note saying dense fine speckled pattern is noted. DNA antibody and smith are negative at that time. Slightly elevated C3 of 186 and normal C4. The only other thing that is out of range was CRP of 6.6. I am hypothyroid and on 75 mcg of Levoxyl with my TSH being in range. The latest test was 4.62 up from 2.95 (four months ago). The ANA cascading reflex result was negative. Does that result mean that the ANA itself was negative? Or the antibody subtlest that are carried out if ANA is positive. I am trying to determine if the subtlest were actually performed or if they were not. I find it hard to believe that my ANA would have been negative at this point.
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Thank you for your reply. I have read that the dense fine speckled pattern can actually make it unlikely that I do have a systemic autoimmune disease. Could this be caused by Hashimoto's disease since I am hypothyroid?
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