Q. I am worried about my ANA report. Please guide me.

Answered by
Dr. Kusumakar Srivastava
and medically reviewed by iCliniq medical review team.
This is a premium question & answer published on Nov 16, 2016 and last reviewed on: Nov 02, 2020

Hi doctor,

I have had a positive ANA for at least 12 years with no other positive tests for autoimmune disease. My other symptoms are fatigue and some joint pain in hands and knees. Recently, I had a positive ANA of 1:640 speckled pattern with a note saying dense fine speckled pattern is noted. DNA antibody and smith are negative at that time. Slightly elevated C3 of 186 and normal C4. The only other thing that is out of range was CRP of 6.6. I am hypothyroid and on 75 mcg of Levoxyl with my TSH being in range. The latest test was 4.62 up from 2.95 (four months ago). The ANA cascading reflex result was negative. Does that result mean that the ANA itself was negative? Or the antibody subtlest that are carried out if ANA is positive. I am trying to determine if the subtlest were actually performed or if they were not. I find it hard to believe that my ANA would have been negative at this point.



Welcome to icliniq.com.

  • You are fine. Please do not worry as nearly all your reports are fine (attachment removed to protect patient identity) and you are taking correct medicines also.
  • As per your ANA (antinuclear antibody) with dense speckled patters is noted, I must say that there are many false positives in the report as even in 20% to 25% patients this is false positive and most important thing is we have to treat you and not the reports.
  • CRP (C-reactive protein) is an acute phase reactant increased in response to activity of disease and becomes normal when activity comes down. So, repeat the test after a month.
  • Till then, I suggest Wysolone 20 mg (Prednisolone) daily after food for 10 days along with other medicines. Consult your specialist doctor, discuss with him or her and take the medicine with consent.

Revert back after 10 days to a rheumatologist online --> https://www.icliniq.com/ask-a-doctor-online/rheumatologist

Hi doctor,

Thank you for your reply. I have read that the dense fine speckled pattern can actually make it unlikely that I do have a systemic autoimmune disease. Could this be caused by Hashimoto's disease since I am hypothyroid?



Welcome back to icliniq.com.

  • Systemic lupus erythematosus - SLE cannot be there as you told anti-DNA is negative.
  • Now, for Hashimoto's disease there are many clinical symptoms other than fatigue like hair loss, unexplained weight gain, sensitivity to cold and dryness. If you want to confirm, then we can go for anti-TPO antibodies to have a look.
  • You are a subclinical hypothyroid, so let us have the report and then follow up. Do not worry.

For further information consult a rheumatologist online --> https://www.icliniq.com/ask-a-doctor-online/rheumatologist

Was this answer helpful?


Related Questions:
What does high hs-CRP indicate?

Raised hs-CRP (high-sensitivity C-reactive protein) indicated your risk to cardiac issues ... My ESR also seems to be higher along with lipoprotein ...   Read full

Is lupus causing all my symptoms?

.. of asthma is doubtful as pulmonary issues are seen in conditions you are already suffering from like SLE (systemic lupus erythematosus) and rheumatoid arthritis. Basically, the right term for you is MCTD (mixed connective tissue disease), which a...   Read full

Pain in my hands and wrists. What does my blood work suggest?

.. antibody as such does not match your symptoms. It is an antibody for autoimmune disease more like SLE (systemic lupus erythematosus). Since it is positive, I would like to know if your ANA (antinuclear antibody) was positive as well, or only this ...   Read full


This is a sponsored Ad. icliniq or icliniq doctors do not endorse the content in the Ad.

Also Read Answers From:

Comprehensive Medical Second Opinion.Submit your Case

Also Read

What Is Epilepsy Or Seizure Disorder?
We all are familiar with the term epilepsy, and always associate it with fits or seizures. But, there is more to it. So,...  Read more»
Can viral fever lead to Parkinson's disease?
Hello doctor,I had a viral fever six years back. I had a very high temperature of 105, bad cough, also hallucinations. I...  Read more»
Parkinson's Disease: Historical Aspects and Current Treatment Approaches
This article discusses the historical aspects of Parkinsonism and, the evidence based approaches currently available for...  Read more»

Ask your health query to a doctor online?

Ask a Rheumatologist Now

* guaranteed answer within 4 hours.

Disclaimer: No content published on this website is intended to be a substitute for professional medical diagnosis, advice or treatment by a trained physician. Seek advice from your physician or other qualified healthcare providers with questions you may have regarding your symptoms and medical condition for a complete medical diagnosis. Do not delay or disregard seeking professional medical advice because of something you have read on this website.