HomeAnswersHIV/AIDS specialistantiretroviralI am having belly fat after taking antiretrovirals. Please advise.

Can taking antiretrovirals cause belly fat?

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The following is an actual conversation between an iCliniq user and a doctor that has been reviewed and published as a Premium Q&A.

Medically reviewed by

Dr. Divya Banu M

Published At July 17, 2019
Reviewed AtJuly 28, 2023

Patient's Query

Hello doctor,

I am HIV(Human Immunodeficiency Virus) negative and have been taking Truvada and Tivicay now for exactly one month but have stopped. I am pretty regular at the gym and maintain a consistent weight of about 146 to 149. Over the past month, I have gained about 5 lbs. At times my stomach looks pregnant and it is always relatively flat. Most of the weight is belly fat. Is there some correlation with the Truvada or Tivicay regimen? Is it temporary or permanent?

Hi, Welcome to icliniq.com.

I wanted to ask you whether you had taken Truvada and Tivicay as post-exposure Prophylaxis? Belly fat changes which you have developed is one of the side-effect of antiretroviralswhich you had taken. The mechanism underlying is not known. As you are not taking medicines now, it is expected to improve. Regular exercise and dietary changes will help you. Also, get your blood pressure, fasting blood sugar and lipid profile done.

The Probable causes

ARV- Dolutegravir.

Investigations to be done

FBS, lipid profile.

Probable diagnosis

ARV toxicity.

Treatment plan

Continue ARV as prescribed.

Preventive measures

Regular exercise, diet changes.

Patient's Query

Thank you doctor,

I did take the medicine for only a precautionary measure of post-exposure but I am HIV negative. So that part is fine. I did have an abdominal CT scan and everything is fine but my stomach is still big. Anything else I should do as my stomach has never been like this. Thank you very much.

Hi, Welcome back to icliniq.com.

If you are not HIV infected, the one month exposure of drugs could not attribute to fat redistribution. If there is sudden body disfigurement, you need to go for general physical examination by a clinician for a decision for appropriate test. It may or may not be lipodystrophyalone​.

Same symptoms don't mean you have the same problem. Consult a doctor now!

Dr. Ravinder K. Sachdeva
Dr. Ravinder K. Sachdeva

HIV/AIDS specialist

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