AST, aspartate transaminase, is an enzyme present mainly in the liver and heart. An AST blood test helps to measure the amount of AST in the blood. It is used in routine blood screening to diagnose liver diseases. The normal range of AST lies between 5 to 40 international units per liter (IU/L) of serum. High AST levels in the blood may indicate cirrhosis, fatty liver, alcoholic liver disease, hepatitis, and mononucleosis.

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My ALT and AST levels are high and found fat on my liver ultrasound. What should I do?

Query: Hello doctor, I am 42 years male with controlled hypertension. I did my annual check-up, and I found ALT and AST are 192 and 142, which are elevated. I had an ultrasound, and I found fat from marked to moderate on my liver. Lipid profile results are in the optimal level, CBC and kidney results also...  Read Full »

Dr. Muhammad Majid Hanif

Answer: Hello, Welcome to Certain prescription and over-the-counter drugs may also cause increased liver enzyme levels. In studies, we have seen that Candesartan (Atacand 8 mg) that you are taking, can cause deranged hepatic function and also inflammation of the liver (hepatitis) to some exte...  Read Full »

What does high value of ALT, AST, and ALP indicate?

Query: Hello doctor, I want to show my LFT report. I was suffering from jaundice. In my first test result total bilirubin was 11.2 mg/dL (D: 2.1, ID: 9.1), and the values of ALT, AST, and ALP are 53, 41, and 162 u/l, respectively. Hepatitis B was negative. In my second test results, the total bilirubin c...  Read Full »

Dr. Goswami Parth Rajendragiri

Answer: Hello, Welcome to I can understand your concern and the following is my opinion about your asked question. ALT (alanine transaminase) or SGPT (serum glutamic pyruvic transaminase) is the liver cells' enzyme. So, raised the level of which is suggestive of liver cell (hepatocyte) damag...  Read Full »

My mom is diagnosed with autoimmune hepatitis with high ALT and AST levels. Please help.

Query: Hello doctor, My mom was diagnosed by chance with the liver disease about three months ago when she did some routine blood tests. Her values then were: ALT = 157 U/L. AST = 106 U/L. ALP = 727 U/L. GGT = 575 U/L. She had ultrasound and CT tests, but nothing wrong showed up with her liver at all. She...  Read Full »

Dr. Ghulam Fareed

Answer: Hello, Welcome to I read your query and can understand your concern. I am reviewing your case history in detail and will get back to you shortly. Thanks and take care.  Read Full »

Could cocaine use two days before blood draw cause the LFTs to be elevated?

Query: Hello doctor, Could cocaine use two days before blood draw cause the LFTs (ALT=90 and AST=86) to be elevated? If so, how long of an abstinence period (not using cocaine) would be needed to get LFTs back down to normal levels?  Read Full »

Dr. Vivek Chail

Answer: Hi, Welcome to I have read through your query in detail. Please find my observations below. Taking cocaine two days earlier can increase the LFTs. LFTs can also be raised due to many causes including liver infection, increased alcohol intake, intake of toxic chemicals including cocaine,...  Read Full »

I have chest pain and acid reflux with raised AST and ALT levels. Why?

Query: Hello doctor, I recently went to the ER for persistent and sharp chest pain. It was diagnosed as a bad acid reflux spell but was told to follow up with a GI doctor in case it was an ulcer. The doctor noted slightly high protein levels but I am looking at my chart and I have high AST and ALT levels....  Read Full »

Dr. Ajeet Kumar

Answer: Hello, Welcome to I can understand you must be concerned and very upset about your recent onset symptoms and visit to ED for this chest pain. Yes, they are right, that you might have ulcers in the food pipe that has led to chest pain. But you see, the patients with ulcers in food pip...  Read Full »

Does intake of Xarelto cause an increase in AST and ALT?

Query: Hi doctor, I am taking Xarelto 20 mg daily for DVT from the past four weeks. My blood work shows increased AST, which is double than normal, and ALT, which is triple than normal. Should I take today's dose? I take a lot of medicines for different health conditions. I have attached the photo of my pr...  Read Full »

Dr. Goswami Parth Rajendragiri

Answer: Hello, Welcome to I have seen the attached prescription (attachment removed to protect patient identity). You are taking Alendronate, Alprazolam, Rivaroxaban, and Simvastatin for your different conditions. For example, Alendronate for osteoporosis, Simvastatin for hyperlipidemia, and...  Read Full »

My WBC count is low, and my AST/ALT ratio is 2.129. Should I be worried about my AST and ALT levels?

Query: Hello doctor, I am a 20-year-old male. I have been prescribed the tablet Adderall. I do not take drugs or alcohol. Five years ago, I went to the doctor for a palpable cervical lymph node that measured 1.5 cm on an ultrasound. They told me to return if it did not go back in a couple of months, and I ...  Read Full »

Dr. Rajesh Gulati

Answer: Hello, Welcome to If it is lymphoma, it would have significantly grown by now. From the attached images (attachments removed to protect the patient's identity), it does not seems to be some benign enlargement. You should not worry about it. Still, a biopsy should be done to confirm t...  Read Full »

My AST and ALT levels are 92 and 143 respectively, and I am ANA positive. Should I be worried?

Query: Hi doctor, I am sharing my blood profile and ultrasound results details to get some insightful feedback. I am 29-year-old female with a weight of 130 kg and 5’7 height. I am currently on Levothyroxine and Sertraline. My AST levels were 92 U/L, and my ALT was 143 U/L. My physician has also suggeste...  Read Full »

Dr. Mashfika N Alam

Answer: Hi, Welcome to I understand your concern. Could you specify how long you have been taking Levothyroxine? I know you are concerned about your medical condition, but Levothyroxine can also cause deranged liver enzymes as it undergoes hepatic metabolism. Since you have no symptoms like...  Read Full »

AST and ALT levels are high since the 11th week of pregnancy. Is it alarming?

Query: Hello doctor, I am 21 weeks pregnant, and I have all my tests done. All of it seems well. The only concern is the baby is having an echogenic intracardiac focus in left ventricle which was found in anomaly scan following which my doctor prescribed a quad screen test and I did that as well. My doctor...  Read Full »

Dr. Balakrishnan R

Answer: Hello, Welcome to How are you doing? Let me assure you that you and your baby are absolutely normal and will have no problems. Let me explain one by one. A single soft tissue marker like the echogenic cardiac focus is not at all to be worried about. We do not need to do any marker or ev...  Read Full »

Kindly explain about the AST and ALT levels in blood report.

Query: Hello doctor,I am 55 years old male, height 168 cm, and weight 74 kg. I do not drink or smoke. Presently, I am not under any medications. Previously, I took medicines for suspected acid reflux symptoms for six months but stopped since one year. I used to undergo comprehensive blood tests on a yearly...  Read Full »

Dr. Kannane Tirougnanassambandare

Answer: Hi, Welcome to I note that your query is related to abnormal LFTs (blood liver function tests) SGOT (AST- aspartate transaminase) and SGPT (ALT- alanine transaminase). From the information you provided (attachment removed to protect patient identity), I understand that: You are asym...  Read Full »

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