My AST and ALT levels are 92 and 143 respectively, and I am ANA positive. Should I be worried?

Q. What does having elevated liver markers and a positive ANA test report indicate?

Answered by
Dr. Mashfika N Alam
and medically reviewed by iCliniq medical review team.
This is a premium question & answer published on Oct 26, 2022

Hi doctor,

I am sharing my blood profile and ultrasound results details to get some insightful feedback. I am 29-year-old female with a weight of 130 kg and 5’7 height. I am currently on Levothyroxine and Sertraline. My AST levels were 92 U/L, and my ALT was 143 U/L. My physician has also suggested to take an ultrasound as I have undergone a minor splenectomy, and everything was normal in the ultrasound. ANA was positive, so I was also thinking of seeing a rheumatologist and possibly a liver specialist if needed. Ceruloplasmin, iron, lipase, analyse, and ferritin levels were within normal range.

Also, I recently got Mirena removed one and a half months ago, which is an intrauterine device, as it may be a triggering factor. My blood profile is the same as the initial results. I have undertaken an ultrasound one and half months after the removal of the spleen and found that the spleen has shrunk by a centimeter and is now in the normal range.

So I want your opinion as I am not experiencing symptoms now, and all screening tests were in the normal range.



Welcome to

I understand your concern.

Could you specify how long you have been taking Levothyroxine?

I know you are concerned about your medical condition, but Levothyroxine can also cause deranged liver enzymes as it undergoes hepatic metabolism. Since you have no symptoms like this, it could be your case.

Also, abdomen ultrasound showed no abnormality in the liver, it is excluded from other conditions like fatty liver.

I suggest you not to stop or reduce the dose of Levothyroxine without an endocrinologist's advice and also undergo thyroid tests. Then, if necessary, the dose can be reduced.

Kindly mention if you have any other symptoms.

I hope this helps.

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