Common "Autoimmune Pathology" queries answered by top doctors | iCliniq

Autoimmune Pathology

Autoimmune disease is a condition where the body's immune system attacks the healthy cells in the body. The pathogenesis of autoimmune diseases are genes, the immune system, and the environment where the affected person lives. The immune system gets dysregulated and causes pathological changes in the body. Common autoimmune disorders affecting the body are Addison's disease, Graves' disease, Hashimoto's thyroiditis, multiple sclerosis, diabetes type 1, and pernicious anemia.

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What does borderline positive c-ANCA levels indicate?

Query: Hello doctor,My c-ANCA levels are 5.6 U/ml (borderline positive). I have hypertension and proteinuria (3g), high serum creatinine (2.4), and UTI. My other autoimmune tests and serum electrophoresis results are negative. What should I do and what is the general prognosis?  Read Full »

Dr. Anshul Varshney

Answer: Hi, Welcome to Based on your query, my opinion is as follows: C-ANCA (antineutrophil cytoplasmic antibodies) positivity indicates Wegener's Granulomatosis. In this condition, there is involvement of the upper and lower respiratory tract and kidneys. The most common diagnosis, while ki...  Read Full »

Can I rely on fourth-generation HIV test result after six months of exposure?

Query: Hello doctor, How accurate is HIV test after six months? What are the things that affect or delay the HIV test? I am taking Ashwaghanda, does it delay my test? When should I test if I have an autoimmune disease?  Read Full »

Dr. Purushottam Sah

Answer: Hello, Welcome to There is a window period of three months after an exposure in which the HIV antibody test may come negative, but six months is a good enough time for the test to become reliable. Ashwagandha does not affect the test. Even if you have autoimmune disease, it means you ...  Read Full »

I married my first cousin. Will this affect our child?

Query: Hi doctor, I have married my first cousin, daughter of my maternal uncle. I would like to know, will there be any genetic issue with our future kid. What are the things we need to take care off? Do we need to take any test? Could you please give some guidance on this. Thank you.  Read Full »

Dr. Megha Tuli

Answer: Hi, Welcome to I understand your situation. Genetic disorders are more likely in such marriages. I am not trying to scare you but if there is any familial disease in your family it would be good to get it checked in early pregnancy. Any autoimmune disease like rheumatoid arthritis, a...  Read Full »

Why do I feel extreme fatigue despite normal blood reports?

Query: Hi doctor, I am suffering from low-grade fever, hair loss, and extreme tiredness. There is pain and burning sensation in my stomach along with loss of appetite and weight gain. I got my ANA test done and it came positive. My ESR level has increased. All my other test results found to be negative. Pl...  Read Full »

Dr. Hariharan V

Answer: Hi, Welcome to I went through your reports (attachment removed to protect patient's identity) and observed that there is no autoimmune disease present. Since you have been suffering from multiple joint pains for the past one year, you should have tested for rheumatoid arthritis (RA) f...  Read Full »

Why are there tremors, speech problems and memory disturbances?

Query: Hello doctor, For the past few years, I have been having the following symptoms: 1) Tremors. 2) Pain near the spinal cord. 3) Head stiffness. 4) Getting stuck when thinking or solving things. Please advise.  Read Full »

Dr. Jaydeep Tripathy

Answer: Hi, Welcome to I would like to know the following details: 1) May I know your age? 2) Do you have any history of hypertension or diabetes? 3) Do you have any history of previous tuberculosis? I will suggest an immediate MRI (magnetic resonance imaging) of the brain to rule out deg...  Read Full »

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