Q. Is it safe to administer Benzodiazepine in a patient taking Phenibut and Kratom during general anesthesia?

Answered by
Dr. Yatish Anant Jadhav
and medically reviewed by Dr. Divya Banu M
This is a premium question & answer published on Jan 14, 2020

Hello doctor,

I am going to be under general anesthesia in coming days for surgery. I did let my pre-op nurse know and wrote down all current medicines and supplements but have a question about 2 supplements. As I am not going to take them the night before anyways but just wanted insight. The first is Kratom. I wanted her to know so the anesthesiologist could dose my pain medicines right during surgery. Second is Phenibut F.A.A. (Free Amino Acid) would this would this have any effect on tolerance to the Benzodiazepine they choose to administer?

Dr. Yatish Anant Jadhav



Welcome to icliniq.com.

You are taking 2 drugs one of which is Psychoactive compound (Kratom) while other one is mind calming magnet (Phenibut). If you are taking those drugs since long time then you may have some tolerance to Opioids/Benzodiazepines/other sedative anesthetic medicines. So I would suggest you personally inform the anaesthesiologist regarding them so that he can make necessary adjustments in dose of anesthetic agents. I just have added effects of these medicines on body.

Kratom contains psychoactive compounds Mitragynine (C23H30N2O4, molecular weight 398.49) and 7-hydoxymitragynine (7-HMG). It is used to treat chronic pain or opioid withdrawal, although no scientific evidence supports this use. The leaves are used for recreation and for self-medicated opioid withdrawal treatment.Kratom's toxic effects include dry mouth, changes in urination, nausea, vomiting, and weight loss. Serious complications, such as seizures and coma, have been reported. The effects of Kratom are dose dependent. Small doses produce cocaine-like effects; larger doses cause morphine-like sedative effects. Kratom users report increased work capacity, alertness, sociability, and sometimes increased sexual desire. Phenibut is a modified version of gamma-aminobutyric acid (GABA) which is one of the inhibitory neurotransmitters in the brain. It exhibits a relaxing effect and is also describe as producing a euphoriant, dis-inhibiting and calming state of mind.

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