HomeAnswersPathologybreast cancerMy wife’s biopsy report shows grade 2 breast cancer. Kindly help.

Can a biopsy report show distant metastasis in a woman with grade 2 breast cancer?

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The following is an actual conversation between an iCliniq user and a doctor that has been reviewed and published as a Premium Q&A.

Medically reviewed by

Dr. K. Shobana

Published At March 18, 2023
Reviewed AtOctober 11, 2023

Patient's Query

Hi doctor,

This is for my wife's breast cancer report. I want your opinion on the case and pathology report. As you can see in the biopsy report, it is the grade 2 ( T3, N1, M1). Will it be the same as the specimen after the surgery? Can biopsy show distant metastasis? And lump node? Please advise. Best regards.

Answered by Dr. Utkarsh Sharma

Hi,

Welcome to icliniq.com.

I understand your concern. I have seen the attached reports (attachments removed to protect the patient's identity). The Nottingham scale is used to classify the grade of the tumor. A score is given according to histology. The higher the score, the poor is differentiation and the higher the grade. Grade 2 is moderate differentiation. The score is more reliable on the resection specimen. Surgery is indicated as the tumor histology is that malignant. Testing is also required, and it is called FISH (fluorescent in situ hybridization), the results of which will guide further treatment. This testing will be done on the biopsy tissue. To answer further to your query, a resection will include axillary lymph nodes as well, and then the staging will be done. Resection, however, will not tell about distant metastasis. A PET scan (positron emission tomography) can be useful. I hope I answered your queries and understand the overwhelming emotions in these difficult times. But I hope for a good prognosis as the lesion is very small. Take care and all the best.

Same symptoms don't mean you have the same problem. Consult a doctor now!

Dr. Utkarsh Sharma
Dr. Utkarsh Sharma

Pathology

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