Patient's Query
Hi doctor,
I am a 41-year-old female, and my mother had breast cancer at 50, and my uncle had colon cancer at 60. I have not had cancer, but I am thinking about cancer genome testing. What should women know before doing these tests? Will it really change what screenings I get? My cancer antigen 125 was mildly elevated at 41 U/mL; does that mean something serious?
Please advise.
Hi,
Welcome to icliniq.com.
I read your query and understand your concern.
I am really sorry to hear that you have a family history of breast cancer and colon cancer. That makes you a strong candidate for genetic testing in order to detect whether cancer is present, and if it is, to identify it at an early stage so that the best treatment approach can be given.
The genetic testing may include BRCA1 (Breast Cancer gene 1) and BRCA2 (Breast Cancer gene 2), PALB2 (Partner and Localizer of BRCA2) for breast cancers, and for Lynch syndrome MLH1 (MutL Homolog 1), MSH2 (MutS Homolog 2), and MSH6 (MutS Homolog 6). I suggest consulting a medical or surgical oncologist so that they can proceed with the testing and guide you with the best approach.
Screening will change if those tests turn out positive. You will need more frequent mammograms (yearly), breast examinations every three to six months, and magnetic resonance imaging, while colon cancers require a colonoscopy.
There is also the option of risk-reducing surgeries, especially for women who have completed their families and are BRCA positive. Prophylactic mastectomy with bilateral salpingo-oophorectomy can reduce the risk of breast cancer by up to 90 percent.
Your cancer antigen 125 is mildly raised (normal range is less than 35), which can also be elevated in benign conditions. If you do not have symptoms such as pelvic pain, there is usually nothing to worry about, but to be on the safe side, I suggest doing a transvaginal ultrasound.
I hope this answers your query.
Let me know if I can assist you further. I would appreciate your feedback.
Thank you.
Was this conversation helpful?
Answered byDr. Mohamed Abdirahman Ali
Medically reviewed byiCliniq medical review team
Same symptoms don't mean you have the same problem. Consult a doctor now!
Disclaimer: No content published on this website is intended to be a substitute for professional medical diagnosis, advice or treatment by a trained physician. Seek advice from your physician or other qualified healthcare providers with questions you may have regarding your symptoms and medical condition for a complete medical diagnosis. Do not delay or disregard seeking professional medical advice because of something you have read on this website. Read our Editorial Process to know how we create content for health articles and queries.