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Q. Why are men affected by cancer more than women?

Answered by
Dr. Sadaf Mustafa
and medically reviewed by iCliniq medical review team.
This is a premium question & answer published on May 20, 2016 and last reviewed on: Mar 07, 2020

Hi doctor,

Why are men generally affected by cancer than women? Do they have less tumor suppressor genes (p53) than women? Or is there a different reason entirely?

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Hello,

Welcome to icliniq.com.

  • There are various reasons for cancer in general and p53 is one of the many genes that can cause cancer.
  • These are sporadic mutations and no sex is more prone to have p53 mutations than the other. But, yes the p53 mutations are seen in more male dominant cancers like prostate cancer and myelodysplasia (bone marrow cancer).
  • Some of the cancers are more common in women like breast cancer than men; similarly lung cancer is on the rise in females as well.
  • It depends upon the risk factors such as smoking, sexual lifestyle, family history and environmental exposures.
  • There is a change in trend over many years and now we are seeing mixed results.

For further information consult an internal medicine physician online --> https://www.icliniq.com/ask-a-doctor-online/internal-medicine-physician


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