Will CT scan help in determining the malignancy status of an enlarged lymph node?

Hi,

Welcome to icliniq.com. Computed tomography (CT) is a structural imaging method that relies on assessment of lymph nodes (LNs) based on their anatomy viz. size, shape, margins and enhancement patterns. Among these, size is still the most common criterion, a short axis diameter of more than 0.39 inch is generally accepted as a threshold for malignancy in most studies. However, the diagnostic sensitivity of this standard is weakened by the fact that many a times malignant LNs can be normal in size (false negative) and many infective nodes can be enlarged in size thus giving false positive results on imaging. Nowadays, CT is combined with PET (Positron emission tomography) to get both anatomical and functional information. It is called fusion imaging and is mainly used to diagnose and stage metastatic cancers such as lymphomas. CT also uses ionizing radiation (X-rays) that is another disadvantage which needs to be considered. So to sum it all, structural imaging methods such as ultrasound, CT, conventional magnetic resonance imaging (MRI) do not distinguish benign LNs from malignant ones with 100 % accuracy. Conversely functional imaging methods such as DWI (diffusion weighted), PET have low spatial resolution and are time consuming. Therefore now we are seeing a shift towards fusion imaging techniques such as DWI-T2 weighted image (T2W)1 MRI, PET/CT, etc., as these techniques bypass the above mentioned shortcomings.