What should be done to control depressive symptoms, which persist despite taking medications?

Hello doctor,

I am a female and I have been suffering from severe recurrent depression for over three years with feelings of hopelessness and worthlessness, suicidal and self-harm behaviors, anti-social behaviors and social withdrawal, low mood and self-esteem, and increased appetite and sleeping. I have been on tablet Mirtazapine for nearly two years now. I have found that it has played a critical role in my recovery and whenever I have stopped taking it, I have experienced a rapid deterioration in my mental health. In the past, I have undergone treatments for an atypical eating disorder, binge eating disorder, personality disorders (borderline, OCPD, EUPD), and social anxiety linked to depression for which I have been hospitalized. However, over the past two months, I have felt that my depressive symptoms are coming back again. Currently, I am taking Mirtazapine, Lamotrigine, and Melatonin. Earlier I was taking Fluoxetine, Sertraline, Citalopram, Olanzapine, Quetiapine, Aripiprazole, Lorazepam, Clonazepam, and Promethazine. I wanted to find out what other anti-depressants are effectively taken with Mirtazapine, particularly Venlafaxine, and Bupropion, as I have taken antipsychotics in the past which have caused significant weight gain and affected my binge eating. I do not want to take anything that would cause weight gain. I have already tried Fluoxetine, Sertraline, and Citalopram before starting Mirtazapine and found that not only they did not help, but also caused some symptoms which made my condition worse.