Double Marker

Double marker test is done to access the risk of delivering a child with Down syndrome. It is generally done between 8 and 14 weeks of pregnancy. It is used to detect Down syndrome (trisomy 21) and trisomy 18, which are chromosomal defects.

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What is the risk of trisomy 21 from my NT scan and double marker test?

Query: Hi doctor, I had an NT scan and a double marker test at 12 weeks and five days of pregnancy. The report is as follows. Maternal serum screen 2: Dual test. (CLIA) HCG, Free Beta 69.00 ng/mL equivalent to 1.81 Corr.MOM's PAPP-A 1.40 mIU/mL equivalent to 0.36 Corr.MOM's Disorder screen positive cut ...  Read Full »


Dr. Deepti Verma

Answer: Hello, Welcome to icliniq.com. I have gone through your question and understand the concerns. I have reviewed the report (attachment removed to protect the patient's identity). It shows an increased risk in the first-trimester screening. You should go for amniocentesis at 16 weeks gestation to rul...  Read Full »

What is the risk of baby being born with Down's syndrome?

Query: Hello doctor, My wife underwent double marker test. Results are as follows. Please tell me if there is any risk factor regarding the pregnancy. Her age is 31 years. PAPP-A : 0.35 MoM, fb-hCG 2.14 MoM, age risk 1:743, biochemical T21 risk 1:54, combined trisomy 21 risk 1:226, trisomy 13/18 + NT.  Read Full »


Dr. Ravinder Kaur Khurana

Answer: Hello, Welcome to icliniq.com. Yes, there is a risk of the baby being born with Down's syndrome. To confirm it, there is a test called chorionic villus sampling, where the sample of the placenta is taken, and chromosomal analysis is done to rule out trisomy 21, 18, and 13, which are abnormal chrom...  Read Full »

My doctor said there is a tumor in the fetus. Kindly provide second opinion.

Query: Hello doctor, Please check my antenatal scan reports for three months pregnancy.  Read Full »


Dr. Mavani Jimesh Himatbhai

Answer: Hello, Welcome to icliniq.com. I have gone through the reports (attachment removed to protect patient identity). As per the sonography report, the baby is fine with NT (nuchal translucency) of 2.5 mm. Usually, it is around 1 to 1.8 mm and it is said that there is an increased risk of Down's syndro...  Read Full »

What do my NT scan and double marker reports say?

Query: Hello doctor, I am a 31 year old female. I am 12 weeks pregnant. I have received my NT scan and double marker reports. Below are the details: NT 0.70 mm, trisomy 21 and NT 1:675, trisomy 13/18.  Read Full »


Dr. Balakrishnan. R

Answer: Hello, Welcome to icliniq.com. How are you doing? Let me start by saying that you and your baby are absolutely fine. First of all, 31 years is not at all a risk factor. Only after 35 years, the risk of these genetic problems increases a lot, much more after 40 years. These factors are calculated usi...  Read Full »

After missing my NT scan and double marker test, can I take it during the 15th to 16th week?

Query: Hello doctor, Now I am in the 14th week of my pregnancy. I missed the NT scan and the double marker test to be taken between the 11th to 14th week of pregnancy. Can I take the NT scan and double marker test between the 15th to 16th week of pregnancy?  Read Full »


Dr. Manwani Saloni Dilip

Answer: Hello, Welcome to icliniq.com. The NT (Nuchal Translucency) scan and the Double Marker test should be done between the 11th to the 14th weeks of pregnancy only because the values are inaccurate if done later. I suggest you calculate the dates based on the first ultrasound as the exact date can var...  Read Full »

Should I be worried about my second-trimester anomaly scan, which is positive for two markers?

Query: Hello doctor, I am a 31 year old female. My first trimester NT and double marker test showed a very low risk of 1:3690 for DS and 1:100000 for two other abnormalities. During the second-trimester anomaly scan, the doctor found two markers, CP cyst and mild RPD 4 mm and 4.5 mm. I have given blood fo...  Read Full »


Dr. Deepti Verma

Answer: Hello, Welcome to icliniq.com. I have gone through your question and understand the concerns. The risk in serum screening is low. Choroid plexus cyst usually resolves by 26 weeks, if present as a normal variant. A renal pelvis more than 7 mm is abnormal, but more than 4 mm is doubtful. Hence, There ...  Read Full »

Is it risky if the NT scan shows 3 to 5 mm thickness in a three-month pregnant woman?

Query: Hello doctor, I am a 33 year old female, who has a 5 year old baby girl. I had two miscarriages, one two years back at 11 weeks, and one last year at nine weeks. Now, I am three months pregnant, and I had a NT scan, which showed a thickness of 3 to 5 mm. Is this a case of high-risk pregnancy? Doe...  Read Full »


Dr. Balakrishnan. R

Answer: Hi, Welcome to icliniq.com. How are you doing? Let me put forth few facts. Your age is in normal limits and not in high-risk for anomalies or genetic problem. Only after 37 to 40 years it is high-risk. You do not seem to have any medical complications. You have one 5 year old child, so the cha...  Read Full »

Are my NT scan reports normal?

Query: Hello doctor,I had the NT scan at 11 weeks and 4 days and the NT was 3.3 mm. After that, I got the double marker test done which came back normal, with a risk of 1:624 for T21 and 1:685 for T13 and T18. I was asked to do the NT scan again and at 12 weeks and 2 days, the NT measured 2.8 mm. Also, the...  Read Full »


Dr. Neha Rathod

Answer: Hello, Welcome to icliniq.com. I have gone through your query. There is nothing to worry about. All the reports are fine and your baby has no anomaly. So, relax and do not worry. You need not go for any further invasive procedures like amniocentesis. Just get your TIFFA (targeted imaging for fetal a...  Read Full »

Can you please interpret the results of my double marker test?

Query: Hi doctor, I want to know about the double marker test results. I am uploading the reports.  Read Full »


Dr. Sameer Kumar

Answer: Hello, Welcome to icliniq.com. I have seen the reports (attachment removed to protect patient identity) and understand your concern. The result is in the high-risk zone, and the next test would be a quadruple test done after two weeks to check for risk of aneuploidies. For more information consult a...  Read Full »

Can a temperate pool at 98 F affect the baby during pregnancy?

Query: Hello doctor, I found out that I am pregnant, and the next day I went to a spa. Knowing that hot tub and sauna are not good for me, the lady at the spa told me to go to the temperate pool, which was 98 F. I went for five minutes, and now I am so scared. Did I do something wrong? Please help.  Read Full »


Dr. Sonal Prasad

Answer: Hello, Welcome to icliniq.com. Do not worry, sauna is to be avoided in pregnancy, but not ones with temperature as body temperature. The lady at the spa was wise. Make sure you take your antenatal vitamins throughout pregnancy. For more information consult a doctor soon.   Read Full »

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