Double Marker

Double marker test is done to access the risk of delivering a child with Down syndrome. It is generally done between 8 and 14 weeks of pregnancy. It is used to detect Down syndrome (trisomy 21) and trisomy 18, which are chromosomal defects.

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What do my NT scan and double marker reports say?

Query: Hello doctor, I am a 31 year old female. I am 12 weeks pregnant. I have received my NT scan and double marker reports. Below are the details: NT 0.70 mm, trisomy 21 and NT 1:675, trisomy 13/18.  Read Full »


Dr. Balakrishnan. R

Answer: Hello, Welcome to icliniq.com. How are you doing? Let me start by saying that you and your baby are absolutely fine. First of all, 31 years is not at all a risk factor. Only after 35 years, the risk of these genetic problems increases a lot, much more after 40 years. These factors are calculated usi...  Read Full »

After missing my NT scan and double marker test, can I take it during the 15th to 16th week?

Query: Hello doctor, Now I am in the 14th week of my pregnancy. I missed the NT scan and the double marker test to be taken between the 11th to 14th week of pregnancy. Can I take the NT scan and double marker test between the 15th to 16th week of pregnancy?  Read Full »


Dr. Manwani Saloni Dilip

Answer: Hello, Welcome to icliniq.com. The NT (Nuchal Translucency) scan and the Double Marker test should be done between the 11th to the 14th weeks of pregnancy only because the values are inaccurate if done later. I suggest you calculate the dates based on the first ultrasound as the exact date can var...  Read Full »

Should I be worried about my second-trimester anomaly scan, which is positive for two markers?

Query: Hello doctor, I am a 31 year old female. My first trimester NT and double marker test showed a very low risk of 1:3690 for DS and 1:100000 for two other abnormalities. During the second-trimester anomaly scan, the doctor found two markers, CP cyst and mild RPD 4 mm and 4.5 mm. I have given blood fo...  Read Full »


Dr. Deepti Verma

Answer: Hello, Welcome to icliniq.com. I have gone through your question and understand the concerns. The risk in serum screening is low. Choroid plexus cyst usually resolves by 26 weeks, if present as a normal variant. A renal pelvis more than 7 mm is abnormal, but more than 4 mm is doubtful. Hence, There ...  Read Full »

Is it risky if the NT scan shows 3 to 5 mm thickness in a three-month pregnant woman?

Query: Hello doctor, I am a 33 year old female, who has a 5 year old baby girl. I had two miscarriages, one two years back at 11 weeks, and one last year at nine weeks. Now, I am three months pregnant, and I had a NT scan, which showed a thickness of 3 to 5 mm. Is this a case of high-risk pregnancy? Doe...  Read Full »


Dr. Balakrishnan. R

Answer: Hi, Welcome to icliniq.com. How are you doing? Let me put forth few facts. Your age is in normal limits and not in high-risk for anomalies or genetic problem. Only after 37 to 40 years it is high-risk. You do not seem to have any medical complications. You have one 5 year old child, so the cha...  Read Full »

Are my NT scan reports normal?

Query: Hello doctor,I had the NT scan at 11 weeks and 4 days and the NT was 3.3 mm. After that, I got the double marker test done which came back normal, with a risk of 1:624 for T21 and 1:685 for T13 and T18. I was asked to do the NT scan again and at 12 weeks and 2 days, the NT measured 2.8 mm. Also, the...  Read Full »


Dr. Neha Singh Rathod

Answer: Hello, Welcome to icliniq.com. I have gone through your query. There is nothing to worry about. All the reports are fine and your baby has no anomaly. So, relax and do not worry. You need not go for any further invasive procedures like amniocentesis. Just get your TIFFA (targeted imaging for fetal a...  Read Full »

Can you please interpret the results of my double marker test?

Query: Hi doctor, I want to know about the double marker test results. I am uploading the reports.  Read Full »


Dr. Sameer Kumar

Answer: Hello, Welcome to icliniq.com. I have seen the reports (attachment removed to protect patient identity) and understand your concern. The result is in the high-risk zone, and the next test would be a quadruple test done after two weeks to check for risk of aneuploidies. For more information consult a...  Read Full »

Can a temperate pool at 98 F affect the baby during pregnancy?

Query: Hello doctor, I found out that I am pregnant, and the next day I went to a spa. Knowing that hot tub and sauna are not good for me, the lady at the spa told me to go to the temperate pool, which was 98 F. I went for five minutes, and now I am so scared. Did I do something wrong? Please help.  Read Full »


Dr. Sonal Prasad

Answer: Hello, Welcome to icliniq.com. Do not worry, sauna is to be avoided in pregnancy, but not ones with temperature as body temperature. The lady at the spa was wise. Make sure you take your antenatal vitamins throughout pregnancy. For more information consult a doctor soon.   Read Full »

Kindly provide an opinion on my NT scan and double marker test.

Query: Hi doctor, I am 12 weeks 3 days pregnant. I got my NT scan and double marker blood test results. NT value 1.7 mm at CRL of 52.6 mm, free beta hCG 1.29 MOM, PAPP-A 0.37 MOM, trisomy 21+NT risk 1:513, trisomy 21 1:214 and trisomy 13/18+NT. What is your opinion?  Read Full »


Dr. Sameer Kumar

Answer: Hello, Welcome to icliniq.com. The NT value (nuchal translucency) is normal as it is less than 2.5 mm, but the overall trisomy 21 risks being 1:214 and together risk 1:513. This ideally calls for a quadruple test after one week. If the cut-off bar in the graph is over the cut-off line, then it calls...  Read Full »

What does it indicate if the double marker test in pregnancy is positive?

Query: Hi doctor,I am in my 29th week of pregnancy. NIPT shows low risk but the double marker test is positive. Kindly go through my ultrasound report and please tell me if everything is fine or not.  Read Full »


Dr. Poonguzhali Liston

Answer: Hi, Welcome to icliniq.com. I went through your report (attachment removed to protect the patient's identity), these are the interpretations of your USG (ultrasound) report: Single fetus, which corresponds to 29 weeks, is adequate growth according to both ultrasound scans and dates. A weight of 1.2...  Read Full »

What to do if my double marker test comes back abnormal?

Query: Hi doctor, I am 13 weeks pregnant. Last week, I underwent an NT scan report, and it was normal, and I gave a double marker blood test. Yesterday from the hospital, they called me for a blood test because the first report shows abnormal. I am so scared whether the second time the double marker test ...  Read Full »


Dr. Tinu Philip

Answer: Hello, Welcome to icliniq.com. First of all, congrats on your pregnancy. Let me clarify that double marker is only a screening test. It is not a confirmatory test. Double markers are not repeated if they are showing a high risk. So if the lab has asked for a second sample, it may be due to some o...  Read Full »

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