Common "Double Marker" queries answered by top doctors | iCliniq

Double Marker

Double marker test is done to access the risk of delivering a child with Down syndrome. It is generally done between 8 and 14 weeks of pregnancy. It is used to detect Down syndrome (trisomy 21) and trisomy 18, which are chromosomal defects.

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What does it indicate if the double marker test in pregnancy is positive?

Query: Hi doctor,I am in my 29th week of pregnancy. NIPT shows low risk but the double marker test is positive. Kindly go through my ultrasound report and please tell me if everything is fine or not.  Read Full »

Dr. Poonguzhali Liston

Answer: Hi, Welcome to I went through your report (attachment removed to protect the patient's identity), these are the interpretations of your USG (ultrasound) report: Single fetus, which corresponds to 29 weeks, is adequate growth according to both ultrasound scans and dates. A weight of...  Read Full »

What to do if my double marker test comes back abnormal?

Query: Hi doctor, I am 13 weeks pregnant. Last week, I underwent an NT scan report, and it was normal, and I gave a double marker blood test. Yesterday from the hospital, they called me for a blood test because the first report shows abnormal. I am so scared whether the second time the double marker test ...  Read Full »

Dr. Tinu Zachariah

Answer: Hello, Welcome to First of all, congrats on your pregnancy. Let me clarify that double marker is only a screening test. It is not a confirmatory test. Double markers are not repeated if they are showing a high risk. So if the lab has asked for a second sample, it may be due to some ot...  Read Full »

Will change in LMP date imply false result in double screening test?

Query: Hello doctor, My menstrual date was on the 4th of the previous month, and I got married in the same month. This my pregnancy test becomes positive and during my abdominal scan doctor said that my baby's NT rate is 3.17 and the nasal bone is short. Five days later again I have done a scan in that my...  Read Full »

Dr. Sanjay Kumar Bhattacharyya

Answer: Hello, Welcome to I have seen your reports. (attachment removed to protect patient identity). During the first scan, your baby was 11 weeks and the NT (nuchal translucency) was 3.17. That was a high value but it has been seen in nine out of ten babies with thickness 2.5-3.5 mm at 11...  Read Full »

Kindly explain my nuchal translucency scan and double marker blood test reports.

Query: Hello, Welcome to Kindly explain my nuchal translucency scan and double marker blood test reports in details. I am very worried due to in NT scan nasal bone could not be discretely seen. Gestational Age (as per USG) is 12 weeks and three days. All report attached here for your guidanc...  Read Full »

Dr. Balakrishnan R

Answer: Hello, Welcome to I do not see any problem in your reports (attachment removed to protect patient identity). Your blood reports and scan are within normal limits. Ultrasound scan is done at this 11 to 14 weeks to find out the most common genetic abnormality of the baby- Down syndrome....  Read Full »

Please explain about the factors help to calculate the risk of trisomy 21.

Query: Hi doctor, My NT scan showed me a range of 1.4 mm and my double marker showed me a risk of 1:20300. But my age risk showed a result of 1:176. Which one has to be considered and what it signifies regarding the risk for trisomy 21?  Read Full »

Dr. Uzma Arqam

Answer: Hi, Welcome to I have gone through the query (attachment removed to protect patient identity). Many factors count for calculating risk. They are age, serum markers, family history, and nuchal translucency. An age-related risk is more after 35 years of age. As you are 38 years old, so ...  Read Full »

In scan, my baby's nasal bone is hypoplastic. Am I at a risk of having Down's syndrome baby?

Query: Hi doctor, I am 19 years old. I am 21 weeks pregnant now. I did an ultrasound yesterday. I was told that my baby is about two weeks smaller than it should be at 21 weeks. I was also told that my baby's nasal bone is hypoplastic and not very visible. My baby is at risk of having Down's syndrome. I w...  Read Full »

Dr. Uzma Arqam

Answer: Hi, Welcome to In the case of a history of irregular periods, there could be a discrepancy between dates and scan finding. So there is no need for worrying. If the growth is not healthy for the baby or if the growth is restricted, then you should take it as a concern. You are going to...  Read Full »

Does the double marker test result point towards Down's syndrome?

Query: Hi doctor, My wife's double marker test results are as below. Age 32 years old, hCGb - 53 ng/ml and Corr MOM 1.08, PAPP-P 653.6 mU/ml and Corr MOM 0.36, T21 - 1:224 age cut off 1:596 and cut off 1:250. What is the risk of Down's syndrome?  Read Full »

Dr. Uzma Arqam

Answer: Hi, Welcome to She is 32 years old. I do not have her complete gynecology, obstetrics, medical, previous family and drug history actually but at 32 years of age, the risk is not as much as elderly pregnant ladies at 40 years of age or above. So age-wise low risk as you have described ...  Read Full »

What is the risk of baby being born with Down's syndrome?

Query: Hello doctor, My wife underwent double marker test. Results are as follows. Please tell me if there is any risk factor regarding the pregnancy. Her age is 31 years. PAPP-A : 0.35 MoM, fb-hCG 2.14 MoM, age risk 1:743, biochemical T21 risk 1:54, combined trisomy 21 risk 1:226, trisomy 13/18 + NT.  Read Full »

Dr. Ravinder Kaur Khurana

Answer: Hello, Welcome to Yes, there is a risk of the baby being born with Down's syndrome. To confirm it, there is a test called chorionic villus sampling, where the sample of the placenta is taken, and chromosomal analysis is done to rule out trisomy 21, 18, and 13, which are abnormal chrom...  Read Full »

Do my double marker test results show any complication?

Query: Hi doctor, I am 13 weeks pregnant. I got a double marker test, mentioned below are the findings: hCG free beta-62.50 ng/mL. PAPP-A - 7.17 mlU/mL Trisomy 21-1:250 Trisomy 18/13 -1:100 NT-1.00 mm NT MoM's -0.63 MoM CRL -61.8 mm Is there any complication?  Read Full »

Dr. Sravanthi Nuthalapati

Answer: Hello, Welcome to I have gone through your attached dual screen report and it shows low risk for all the chromosomal abnormality which is absolutely normal. It should be kept in mind that this is a screening test which calculates the risk of carrying a baby with chromosomal abnorma...  Read Full »

What is the risk of Down's in my wife's double marker report?

Query: Hi doctor, This is the report of double marker test of my wife: Corrected MoM and calculated risks: fb-hCG 165 ng/ml 3.82 Corr. MoM PAPP-A 1.84 mlU/ml o.45 Corr. MoM Ultrasound data: Nuchal translucency 1.00 mm CRL 60 mm 0.64 MoM Gestational age by CRL 12+ 2 Nasal bone present Gestational age on th...  Read Full »

Dr. Sravanthi Nuthalapati

Answer: Hello, Welcome to To explain you the report in plain language, first of all, let me tell you that the dual marker test is just a screening test for Down's syndrome and other chromosomal anomalies like trisomy 13/18. So, the test involves calculation of the risk of carrying a Down's...  Read Full »

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