HomeAnswersObstetrics and GynecologypregnancyI am 29 years old and pregnant for the second time. Please interpret my double marker test results.

What do the double-marker laboratory test results suggest about the risk of trisomy?

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Answered by

Dr. Uzma Arqam

Medically reviewed by

iCliniq medical review team

Published At May 20, 2023
Reviewed AtJanuary 30, 2024

Patient's Query

Hello doctor,

My age is 29, and I am pregnant for the second time. I am 11 weeks and 6 days pregnant. Recently, my doctor advised me of a double marker test. The PAPP-A is 0.48 MoM, and FB-hCG is 0.33 MoM. The calculated risk for trisomy 13/19 is 1:3142 and shows low risk, and the calculated risk for trisomy 21 is below the cut-off and shows a low risk. I have undergone an NT scan and taking the medications Folshine and Susten 200. Please explain if my report is fine.

Answered by Dr. Uzma Arqam

Hello,

Welcome to icliniq.com.

I thoroughly read your query and understand your concern.

Biochemistry (two hormones levels), nuchal translucency, family history, and female age all combine to calculate risk. It would be better if you send me reports of the same and some detailed history. As you said, the calculated risk for trisomy is 13, and even if 18, it is almost negligible but with serum markers only. Whereas trisomy 21 shows risk below the cut-off value, I think you are telling less than 1:250. PAPP-A (pregnancy-associated plasma protein A) should be 0.5 MoM or more, and yours is a bit less, 0.48 MoM. Actually, the beta hCG (human chorionic gonadotropin) is less and should be 1 MoM or more. Still, your age is not risky for trisomy 21. Whereas, if family history is negative for an anomaly, then it is also a good point for calculating overall risk. Do have a scan around 12 plus weeks for nuchal translucency, and if it is less than 2.9 mm, then it is normal. Do not be tense. Most of the points are in favor of less risk. Have a scan at 20 weeks with expert hands for any anomaly.

I hope things would be better.

Best of luck.

Same symptoms don't mean you have the same problem. Consult a doctor now!

Dr. Uzma Arqam
Dr. Uzma Arqam

Obstetrics and Gynecology

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