Hi,
Welcome back to icliniq.com
I can understand your concern.
According to your statement, you have been suffering from allergic rhinitis, bronchial asthma, bronchitis, digestive problems, sacroiliitis, keratitis, repeated Infections, and raised Ig E (immunoglobulin E) levels. In the case of allergic asthma, both Ig E and eosinophils are engaged in a complex process. In this, they have their own roles. It is considered that Ig E is the main reason for allergic asthma, while raised eosinophil count is a consequence of the whole process, so eosinophilia or raised eosinophil count will always be found in case of allergic asthma.
Again, on the initiation of the Ig E response, it can be further amplified by basophils, mast cells, and eosinophils. This process can also drive more Ig E production, although eosinophils only become expressed when activated. Elevated serum Ig E may result from allergies, infections, immune conditions like hyper Ig E syndrome, tuberculosis, parasitic infestations, EBV (Epstein Barr virus), CMV (cytomegalovirus), HIV (human immunodeficiency virus), gammopathies, Churg Strauss syndrome, some primary immunodeficiency disorders and many more.
Hyper Ig E is a rare primary immunodeficiency disease characterized by recurrent eczema, recurrent staphylococcal skin abscess, other skin problems like viral Infections such as herpes simplex, herpes zoster, molluscum contagiosum, warts, fungal infections like vaginal or vulvar candidiasis, thrush, fungal nail infections, repeated respiratory tract infections like pneumonia, bronchitis, tuberculosis, ear, eye or sinus infections, skeletal and connective tissue disorders like sacroiliitis, bone fractures, anemia like hemolytic anemia, high serum levels of Ig E, eosinophilia as well as other disorders like digestive problems, neurological manifestations and many more.
Eosinophilia can be found in 90 percent of cases, but in the rest 10 percent cases, the number of eosinophils in the blood might be normal like yours. It is an autosomal dominant or recessive form of the disease. Diagnosis of hyper Ig E syndrome is suspected based on symptoms and measurement of serum Ig E levels. Genetic testing can identify gene mutations. It is mainly done to confirm the diagnosis or to help predict inheritance patterns. Lifelong prophylactic antistaphylococcal antibiotics like Trimethoprim or Sulphamethoxazole are the main treatment for hyper Ig E syndrome. Skin problems are treated with hydration, emollient creams, and antihistamines.
If there are infections, even after taking antibiotics and other associated problems, then they should be treated according to their clinical features. The drug Hetrazan contains diethylcarbamazine that belongs to the group of medications known as antihelminthic which is used in the treatment of worm infections and filariasis. Your high Ig E levels may result from parasitic infestations. For this, you have been prescribed this medication.
It is not a habit-forming drug. It is a safe drug. You can use your eye drops and multivitamins, vitamin C as well as the medications you are currently using without any tension. The side effects that you have already mentioned are the common side effects of this medication. Usually, this medication has no serious side effects but, if you have facial swelling, then you should consult your doctor promptly.
Hope I have answered your question.
Let me know if I can assist you further.
Take care.