Q. Are my mood swings, depression, and aggressive reactions due to high estrogen levels?

Answered by
Dr. Rahul Ramji Kackar
and medically reviewed by Dr. Chithranjali Ravichandran
This is a premium question & answer published on Apr 17, 2021

Hi doctor,

I have an estrogen level of 312 pg/ml on an estrogen, total, serum test. The normal range for males is 60-190 pg/ml.

I have high T3 levels as well.

I am a male. I have had mood swings, aggressive reactions, fight or flight response, depression, etc. This has been continuing for quite some time.



Welcome to

I have gone through the reports (attachments removed to protect the patient's identity), I will like to know if you are taking any testosterone supplements as the main source of estrogen in males? Testosterone conversion to estrogen can increase the levels, alcohol intake, liver disease, thyroid abnormality. So I will suggest you get a thyroid function test and LFT done. Eat a protein diet, do regular exercises and incorporate mindfulness and meditation in your routine for stress management. Take some antioxidants and St. John's Wort 500 mg at bedtime for few days.

Hi doctor,

I forgot to include thyroid test results. I have not even had a sip of alcohol this year. Is this an adrenal issue? I had to have a Klonopin prescription years ago because my rage was about to take over my well-being. I have had a strong fight or flight response to things that should not trigger that response.

Thank you for your help.



Welcome back to

I do not think thyroid profile reports to be contributing to it. Yes, estrogen could be coming from adrenals, but they will be contributing to it indirectly only through conversion from testosterone. Before investigating it further, I will suggest you get into a lifestyle modification regimen to deal with your stress. For that, maintain a daily diary to acknowledge the key stressors and to go into it and then to do some meditation, maybe just breath awareness. Tai chi is also a good option to deal with it. Then take St. John's Wort 500 mg daily, holy basil tablet, or green tea. Take some Magnesium 250 mg for two weeks. Correct any Vitamin D or B12 deficiencies. Get into a daily exercise routine and then repeat thyroid profile and estrogen levels after six weeks.

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