Common "Fluorescence In Situ Hybridization" queries answered by top doctors | iCliniq

Fluorescence In Situ Hybridization

Fluorescence In Situ Hybridization (FISH) is a type of cytogenetics, which uses fluorescent probes to allow researchers to locate the position of specific DNA sequences on chromosomes. It is used to diagnose various types of genetic disorders and chromosomal abnormalities.

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What is BCR-ABL positive and Ph-chromosome negative?

Query: Hello doctor, Can you please explain why I would have the gene and not the chromosome? Ph-negative, BCR-ABL-positive CML. The labs pointed to this. I had bone marrow aspiration and biopsy. I saw the doctor again. From all the labs, it looks like there is CD4 and CD8 elevated ratio 16.5, 8 % NK, lymp...  Read Full »


Dr. Singh Smrita

Answer: Hello, Welcome to icliniq.com. Chronic myeloid leukemia (CML) is a hematopoietic disorder, almost always characterized by the presence of the Philadelphia chromosome (Ph), usually due to t(9;22)(q34;q11) or its variants. The Ph results in the formation of the BCR/ABL1 fusion gene, which is a const...  Read Full »

How can we treat a tumor in breast?

Query: Hi doctor, Before a few months, my mother-in-law has got a tumor in her left breast. There is no pain. It had started growing recently in the last four to six weeks, and we consulted oncologists. The results of various tests are out. I wanted to get a second opinion. I have attached reports to you ...  Read Full »


Dr. Pawar Satyajit Jalinder

Answer: Hi, Welcome to icliniq.com. I have gone through the query. But before going ahead with treatment decisions, I need to know a few details: Any comorbidities like diabetes, hypertension, and renal problem? How is her general condition, is she able to carry out her daily activities? What is her ...  Read Full »

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