Q. Is it possible to identify whether the HIV test is a fourth-generation test from the reports?
Hello doctor,
Please see attached the reports for the viral markers (3H) and VDRL and RPR screening along with this query. These tests were undertaken after eight months and 19 days of exposure or 263 days post-exposure. I wanted to confirm if the test used in the attached report for HIV screening is a 4th generation test or not. I have this doubt because the report has not mentioned "4th generation assay". The heading of the test mentions "HIV 1 and 2 antibodies screening test serum," but if we go a notch below the report, it mentions "HIV 1 and 2 and P24 combo test (CMIA),". Please clear up my confusion concerning this.
Thank you.
Hello,
Welcome to icliniq.com.
The HIV (human immunodeficiency virus) test, which is performed, is a fourth-generation test. The fourth-generation test is a combo or a duo test. It looks for both antigens and antibodies of HIV. It is great that your test for HIV, HBV (hepatitis B virus), HCV (hepatitis C virus), and syphilis infection is negative. These would be considered conclusive if there had been no other exposure in the last three months.
Hope this helps. Kindly revert for further queries.
Thank you.
Hello doctor,
For your reference, I have attached one more report here. It comprises a 3H-viral markers panel. This panel was undertaken after the completion of eight months and 12 days of exposure, or 256 days post-exposure. Will this result also be considered conclusive?
Thank you.
Hello doctor,
I have a concern. What do you think is the most accurate measure of any window period? So, for instance, the window period for HIV 1 and 2 antibodies tests is 90 days. Now some experts quote it as 90 days, others as 12 weeks, and some as three months. So all of these, though similar, are different. For example, 12 weeks equates to 84 days, and when taking three calendar months, we may exceed 90 days and fall around 91 or 92 days (depending on the month). So which one should a person follow? Can one get tested on the 91st day of exposure, or should one wait three calendar months to expire, or is 12 weeks also fine?
Kindly help.
Thank you.
Hello,
Welcome back to icliniq.com.
The window period is the time taken for antibodies to develop in the body and then to be detected by a particular test. The revised fourth-generation or advanced testing kits have reduced the window period. In addition, these test kits are highly sensitive and specific to diagnose the infection (if present) and exclude the infection if not there. A person, if exposed to HIV infection, is asked to get the first test at three to four weeks of the exposure. Most people (greater than 95 percent) who get an infection are likely to show positive test results with the recent kits used to screen for the infection. A small group of people (less than five percent) takes longer to develop an adequate antibody response if infected. And almost all persons who are infected (or have the disease) will show a positive test result by the third month. So, a test performed after 90 days is therefore considered conclusive.
Hope this helps. Revert for further queries.
Thank you.
I just have one follow up question.
Can we consider 90 days or 3 months as the same thing? Or should we also include those
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