Common "Fourth Generation Hiv Test" queries answered by top doctors | iCliniq

Fourth Generation Hiv Test

HIV is a sexually transmitted disease which is caused by human immunodeficiency virus. There are various tests to detect the presence of HIV antigens/antibodies. These tests have evolved over time. A fourth-generation test identifies HIV antibodies as well as p24 antigens from the sample. Therefore, this test is more sensitive and helps identify the infection much earlier than a third generation test.

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Screened for HIV after eight weeks of exposure. Is it reliable?

Query: Hi doctor, I did an HIV (Human Immunodeficiency Virus) rapid screening after eight weeks of exposure, and the results came negative. I do not have any other symptoms of HIV. Is this result reliable? Do I need to do other tests?  Read Full »

Dr. Ravinder K. Sachdeva

Answer: Hi, Welcome to The tests available for HIV diagnosis are highly sensitive and specific and gives accurate results. Majority of the people who are infected with HIV develop HIV antibodies by two to eight weeks. Approximately, up to 5 % develop seroconversion by 12 weeks. Your HIV negativ...  Read Full »

I took the HIV combo test on the 32nd day after exposure. Is it a fourth-generation test?

Query: Hi doctor, I took the (Human Immunodeficiency Virus) HIV-1, HIV-2, and p24 tests on the 32nd day after exposure. I am attaching the file. I want to know whether this is a fourth generation test. If yes, what are the chances that a fourth-generation test is negative on the 32nd day and will turn posi...  Read Full »

Dr. Ravinder K. Sachdeva

Answer: Hi, Welcome to The answers to your queries are: The test which has been performed is a fourth-generation test. This test looks for HIV (human immunodeficiency virus) antigens and antibodies. The test result (attachment removed to protect the patient's identity) is negative. If this resu...  Read Full »

Is my test a fourth-generation HIV test?

Query: Hello doctor, Please see attached the reports for the viral markers (3H) and VDRL (Venereal Disease Research Laboratory) and RPR (rapid plasma reagin) screening along with this query. These tests were undertaken after eight months and 19 days of exposure or 263 days post-exposure. I wanted to confir...  Read Full »

Dr. Ravinder K. Sachdeva

Answer: Hello, Welcome to The HIV (human immunodeficiency virus) test, which is performed, is a fourth-generation test. The fourth-generation test is a combo or a duo test. It looks for both antigens and antibodies of HIV. It is great that your test for HIV, HBV (hepatitis B virus), HCV (hepa...  Read Full »

Could taking anti-HIV measures before a negative fourth-generation HIV test affect the test's reliability, and when can such a test be considered conclusive?

Query: Hello doctor,I did a fourth-generation HIV test after 90 days and the result was negative. But some say that the window period is about six months to one year. I had neem leaves, tablet Acyclovir, and antibiotics during those 90 days. Could that have affected the reliability of the test? Kindly expl...  Read Full »

Dr. Ravinder K. Sachdeva

Answer: Hello, Welcome to We will pay close attention to your worries and address all your questions with utmost care. The tests done for HIV (Human Immunodeficiency Virus) diagnosis these days are highly sensitive, specific, and give accurate results. You can surely rely upon your 90 days t...  Read Full »

I got a negative HIV fourth-generation test but have rashes on my legs, a sore throat, and a tingling sensation. Can I still have HIV?

Query: Hello doctor, I had an HIV (Human Immunodeficiency Virus) 4th-generation test after 90 days and it was negative. But now I got rashes on my legs, sore throat, and some tingling sensation in the tongue which are symptoms associated with HIV. Is it possible for an HIV infected to get a negative 4th g...  Read Full »

Dr. Ravinder K. Sachdeva

Answer: Hello, Welcome to I can understand your concern. The symptoms you are having could be due to multiple reasons and cannot be attributed to HIV. In fact, there are no HIV-specific symptoms or signs which can lead to the diagnosis of HIV. A sore throat can occur due to any viral infection...  Read Full »

Can my low WBC be due to an HIV infection or Pfizer vaccine?

Query: Hello doctor, I had a needle stick exposure before 11 months. When I was trying to insert the IV (Intravenous) in a patient, I ended up poking myself accidentally on my finger. I did a fourth-generation HIV(Human Immunodeficiency Virus) antibody test five months before, and it turned out negative. ...  Read Full »

Dr. Ravinder K. Sachdeva

Answer: Hi, Welcome to If the last exposure was before 11 months and there had been no further exposure, then your test result for HIV (human immunodeficiency virus) will be considered conclusive. Fourth-generation HIV test is highly sensitive and is unlikely to miss infection if there is any. ...  Read Full »

After how many days of exposure should I take an HIV test?

Query: Hi doctor, I have attached my HIV (Human Immunodeficiency Virus) reports taken on the 90th and 188th day after exposure for your reference. Both the reports are negative. There was no further exposure. Should I be concerned?  Read Full »

Dr. Ravinder K. Sachdeva

Answer: Hi, Welcome to I have gone through your reports (attachments removed to protect the patient's identity). Your test results will be considered conclusively negative if there is no further exposure. I hope my answer helps in relieving your stress. Please do not hesitate to ask if there ...  Read Full »

Is it necessary to take fourth-generation test even if other HIV tests are negative?

Query: Hello doctor, I had protected exposure followed by P24 antigen after 33 days, fourth-generation P24 Ag, HIV (Human Immunodeficiency Virus) 1 and 2 antibodies (CMIA - Chemiluminescent Microparticle Immuno Assay) after 38 days, and then tridot after 93 days. All reports were negative for all the tests...  Read Full »

Dr. Ravinder K. Sachdeva

Answer: Hi, Welcome to The answers to your queries are: As you mentioned that it was protected sex, and there was no break or slippage of the condom. The risk of acquisition of HIV in this scenario is non-existent. It is great that your HIV test report at both time points is negative. If there ...  Read Full »

Are fourth generation HIV test results reliable?

Query: Hello doctor, I had unprotected intercourse once with CSW(Community Sex Worker) last year. I tested for rapid ICT(Indirect Coombs Test) and PA methods after six weeks of exposure. HIV (Ag/Ab) CMIA test after eight weeks, both negative. I started getting chronic diarrhea for the past six months. A vi...  Read Full »

Dr. Ravinder K. Sachdeva

Answer: Hi, Welcome to Your test results are negative for HIV. If there had been no further exposure, these would be considered conclusive. However, if there is any doubt about the same or test result, there is no harm in getting a repeat HIV antibody test. This will allay your anxiety. Symptom...  Read Full »

Why do I get itching and burning sensation in hands with muscle pain after risky sexual exposure?

Query: Hello doctor, Before three months, I had unprotected sex with a sex worker in her monthly (menstrual) period. After sex, I noticed bleeding from my cut penis. After one week, pain subsided. And after a month, I had sex, and again noticed bleeding from penis wound. I again had protected sex with sex ...  Read Full »

Dr. Ravinder K. Sachdeva

Answer: Hi, Welcome to The recommendations are to get the fourth generation HIV rapid test at the third or fourth week of the exposure. If the result is negative, get a confirmatory HIV rapid antibody test at 90 days (three months) of last exposure. Your negative HIV test result at three months...  Read Full »

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