HomeAnswersHematologygenetic inheritanceDoes someone need to have one Caucasian parent to be Duffy positive?

Is it necessary to have one Caucasian parent to be Duffy positive?

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The following is an actual conversation between an iCliniq user and a doctor that has been reviewed and published as a Premium Q&A.

Medically reviewed by

Dr. Divya Banu M

Published At October 12, 2019
Reviewed AtAugust 2, 2023

Patient's Query

Hi doctor,

Does someone need one Caucasian parent to be Duffy positive if they are African-American with the Duffy Positive Antigen, phenotype fy (a-b+)? The Duffy Positive Antigen is much more common in Caucasians than in African-Americans. African-Americans are usually Duffy Negative or Duffy Null, not Duffy Positive. Can someone have two African-American parents and be Duffy Positive with blood type fy (a-b+)? Please answer all these questions. I need to know.

Hello,

Welcome to icliniq.com.

Hi,

I am glad you chose icliniq for your medical-related queries.

I understand your concern and will try to help you with it.

Below are the answers to your questions according to my opinion.

1. No. To be Duffy-positive, it is not necessary to have one Caucasian parent. The American and African are usually Duffy negative or null type, but minority American African people might show Duffy positivity. So I have answered in that way.

2. You are Duffy positive African- American. So one of your parents might have positivity for Duffy. But your parent does not need to be of Caucasian origin.

3. If only one parent is Duffy positive, you can also be Duffy positive.

If you are looking for paternity checking, then it is better to do genetic testing. Duffy blood group determination is not conclusive in that manner.

Thank you.

I appreciate your trust in icliniq.com and for giving me the chance to serve you.

Our goal is to prioritize your health and help you according to your preferences and needs.

Patient's Query

Hi doctor,

Thank you for the reply.

Does it mean I have European ancestry at all? If so, could it be 50 % African and 50 % European? Based on being heterozygous Duffy Positive, how much European ancestry might I have?

Hello,

Welcome back to icliniq.com.

Hi,

Welcome back to icliniq.com.

I do understand your concern.

Thanks for asking again.

Below are the answers to your questions in my opinion.

1. No, it does not mean you can have 100 % Caucasian (European) origin. You have a small chance of being American or African origin as well.

2. The exact percentage of origin cannot be predicted. But for the Duffy positive origin, there can be approximately 70 % chance of Caucasian and the remaining portion from American or African. However, the prediction of the exact percentage needs to be commented on.

3. You can have a 70 % chance of having Caucasian origin and remaining of African or American origin. If you have doubts regarding paternity, then a genetic study is recommended.

Regards.

Once more, thank you for allowing us to be of service to you.

We value the high level of confidence you have in us!

Patient's Query

Hi doctor,

Thank you for the reply.

Do you mean that my deoxyribonucleoside acid (DNA) ancestry I could be 70% European and the remaining percentage African-American (30% African-American), such as, 70% European and 30% African-American? Or do you mean I have a 70% chance of being European versus African-American if I am heterogenous Duffy Positive?

Hello, Welcome back. Following is my opinion for your asked question You can have 70% chance of acquiring gene from Caucasian origin and 30% chance of acquiring gene from African American origin as far as Duffy positive blood group concerned. I m not talking regrading whole genome. The exact percentage however cannot be predicted as I have answered in my previous answer. If you need to rule out your biological mother or father than molecular testing recommended Hope I have answered your question Let me know if I can assist you further Regards

Patient's Query

Hi doctor,

Thank you for the reply.

I am still confused. In the United States, someone says I am 70% Caucasian and 30% African-American, detailing what they are mixed with. Is this what you mean by saying 70% chance of Caucasian origin and 30% chance of African-American origin? I am not used to anyone stating someone's racial mixture this way. Or do you mean I have a 70% chance out of 100% to get the Duffy Positive gene from a Caucasian ancestor and not saying this is my racial mixture? Please help.

Hi,

Welcome back to icliniq.com.

I do understand your concern.

Thanks for asking again.

Following is my opinion on your asked question.

  1. The Duffy group can have two gene alleles, fy a and fy b.
  2. So one gene might be acquired from one parent and another from a different parent.
  3. However, as I understand, you have only one allele positive in a heterozygous manner.
  4. So you can have the chance of acquiring all genes from one parent only rather than a racial mixture, in my opinion.
  5. However, for determining the biological father or mother, molecular testing is ideal.

Regards.

Once more, thank you for allowing us to be of service to you.

We value the high level of confidence you have in us!

Patient's Query

Hi doctor,

Thank you for the reply.

Your last answer has confused me even more. I am trying to understand if I am possibly 70% Caucasian and 30% African-American, based on being Duffy Positive (Heterogenous)? Are you saying I can possibly be 70% Caucasian and 30% African-American as a total of 100% my ancestry genetic makeup? Or are you saying something else? Please explain.

Hello, Following is my opinion for your asked question. I want to say you can have acquired whole genes either from Caucasian (70% chance) or from African American origin (30%chance) as total of 100% genetic makeup as far as Duffy group concerned. So as far as Duffy group concerned you can probably have acquired whole positive Duffy group genome from either Caucasian or totally from African American I am not saying you are having mixture of gene for Duffy blood group positivity. Hope your concern solved. Regards

Once more, thank you for allowing us to be of service to you.

We value the high level of confidence you have in us!

Patient's Query

Hi doctor,

Thank you for the reply.

What I need clarification on is what you are saying. Are you saying that the fy(a-b+) Duffy positive heterozygous means the person is 70% European and 30% African, similar to an ancestry composition results from 23 and me?

Or are you saying the person has a 70% chance of being European and 30% chance of being African and not saying they are 70% European and 30% African as in an ancestry composition by 23 and me?

Are you saying the person is a Quadroon (a person that is 70% European and 30% African), based on being Duffy Positive and Duffy Negative heterozygous, fy(a-b+) Duffy Positive Blood Type?

Hello, Welcome back. Following is my answer for your asked question. You can have 70℅ chance of acquiring Duffy positive gene from Caucasian origin and 30% chance of acquiring gene from African American origin. I am not saying you have racial mixture. The chance of racial mixture is less in your case. I want to say that either you have gene for Duffy from Caucasian origin or from American African origin. Hope I have answered your question Let me know if I can assist you further Regards

Once more, thank you for allowing us to be of service to you.

We value the high level of confidence you have in us!

Same symptoms don't mean you have the same problem. Consult a doctor now!

Dr. Goswami Parth Rajendragiri
Dr. Goswami Parth Rajendragiri

Pathology

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