What does the gradual increase in my mother's MCV and MCH indicate?

Hi doctor,

My mother, who is 60 years old, is currently under treatment for hypothyroidism, hypertension and stage 2 osteoarthritis of knee joints. She is currently on the following medicines: Eltroxin 50 mcg, Olmezest 20 mg, Gemcal D3 and E-cod Plus. I have attached a copy of her recent kidney, thyroid, lipid and hemogram reports. Her Hb is reported as 10.8 with the blood smear report mentioning RBCs mild anisopoikilocytosis. Predominantly macrocytic normochromic with macroovalocytes. Platelets appear mildly reduced in smear. Macroplatelets are seen. Following this, our doctor advised to test ferritin, B12 and folic acid. It came as normal, although the samples were provided after mild breakfast.

Another thing I wanted to mention is that last year also, she was diagnosed with mild anemia with Hb 10.6 and ferritin 39. However, following Orofer XT for three months her Hb was improved to 12.4. After that due to gastritis issues, the doctor had advised her to take Orofer XT once a week and it was stopped three months back. At that time, her Hb was 12.0.

Thank you doctor,

As you mentioned there could be previous infections. She had mild loose motion and gastritis around 1.5 months back, which lasted for two weeks, even though antibiotics (Cifran-CT) were given. I have a few follow-up questions. Based on the current reports, how do we rule out the possibilities of GI bleeding or tumor? What is the clinical significance of the mild reduction in platelet counts and the presence of macro platelets as mentioned in the smear report? Is her weight loss (156 to 147 lbs) during the past year something worrisome? For the past couple of years, I have seen a gradual increase in her MCV values (91, 94, and 111) and an increase in MCH (27, 29, and 31) while a decrease in MCHC (33, 31, and 28) irrespective of increase or decrease in Hb. What does this mean?