Q. My HIV testing at 11 weeks was negative. Should I retest at 12 weeks?

Answered by
Dr. Kakkar
and medically reviewed by iCliniq medical review team.
Published on Jan 24, 2018 and last reviewed on: Aug 07, 2019

Hello doctor,

I had cunnilingus with an escort. After this encounter, I had an RNA PCR test at 15 days and anti-HIV 1 and 2 as well as p24 antigen test after two, four, six, eight and 11 weeks. All the results were negative. But, while some websites say that the result is conclusive after eight weeks, some of them say 12 weeks is conclusive. Please tell me if my negative result can change or not.

Dr. Kakkar

Dermatology HIV/AIDS Specialist Venereology
#

Hello,

Welcome to icliniq.com.

I have gone through your query and have noted your concern.

  • HIV (human immunodeficiency virus) antibody screening test is highly sensitive at four weeks and thereafter. It accurately detects a majority (95 % sensitivity) of HIV-infected patients.
  • However, in case of a high-risk exposure such as unprotected vaginal, anal or oral sex with a sex worker, it is advisable to retest at 12 weeks (99.9 % sensitive). The 12-week result is taken as conclusive although it is very rare that a negative result at four weeks would change to positive at 12 weeks.

Regards.

For more information consult an HIV AIDS specialist online --> https://icliniq.com./ask-a-doctor-online/HIV-AIDS-specialist

Hello doctor,

Thanks for the reply. But, as you know I had my last anti-HIV 1 and 2 as well as p24 antigen test at 11 weeks. So, is there any possibility that the result can change in a matter of seven days?

Dr. Kakkar

Dermatology HIV/AIDS Specialist Venereology
#

Hello,

Welcome back to icliniq.com.

  • I do not think that it would turn positive so late. I have never seen that happen in my experience in healthy adults with an intact immunity.
  • As I said, most of the HIV infected individuals will have a positive anti-HIV screening test by three to four weeks and only very rarely the antibody response is delayed, for example, in immunocompromised states or those on immunosuppressive drugs (steroids). Therefore a negative screening test at four weeks and any subsequent negative tests over the ensuing weeks should be followed up by a final 12 weeks screening test for HIV antibodies for a conclusive result to cover for those rare late seroconverters.
  • Only a negative third-generation screening test for HIV antibody at 12 weeks is considered conclusive because those rare few individuals with immunodeficiency or on immunosuppressive treatment may develop a delayed antibody response by 12 weeks.

Regards.

For more information consult an HIV AIDS specialist online --> https://icliniq.com./ask-a-doctor-online/HIV-AIDS-specialist

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