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Q. Are HIV 1 RNA PCR test and duo combo test post-exposure for HIV conclusive?

Answered by
Dr. Rakesh Kumar Bahunuthula
and medically reviewed by iCliniq medical review team.
This is a premium question & answer published on Oct 27, 2022

Hello doctor,

I have done HIV 1 RNA PCR 12 days after exposure, followed by a duo combo test on the 37th-day post-exposure, and both came negative and non-reactive. Can I take these two tests as conclusive? Do I need further testing?

I have taken the opinion of 2 other HIV specialists, and they both say I am safe and do not need further testing as these two tests are very accurate and are done within the window period.

Please advise.

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#

Hello,

Welcome to icliniq.com.

I can understand your anxiety, and the fear of HIV (human immunodeficiency virus) is pretty much a stressful state. HIV has a window period of 12 weeks post-exposure. During the test, results can be false negative.

However, the 4th generation combo test has very high sensitivity and specificity and can be considered conclusive beyond four weeks of exposure. As in your case, the result is negative; thus, you can take it to be definitive. Additionally, you also need to screen for other STDs (sexually transmitted diseases) such as HBsAg, anti HCV, and VDRL in addition to HIV.


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