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Can health issues affect HIV test accuracy after 6 months?

This Premium Q&A, reviewed and published, features a real conversation between an iCliniq user and a physician.

Patient's Query

Hello doctor,

I had a possible exposure before November 2019. I do not know the exact date. It was oral sex after that I got tested on 19th April, May 28th, and June 14th 2020 all were rapid tests and negative and enzyme linked immunosorbent assay (Elisa) on 15th June and it was also negative. My question is, can any other underlying disease which is not diagnosed affect my HIV test results? Can any unknown health conditions give a false negative? It is now 6 months and 22 days for the Elisa is it conclusive?

Please help.

Thank you.

Hi,

Welcome to icliniq.com.

I completely understand your concerns.

Welcome to icliniq.com. If you have tested three times in April, May, and June, and exposure is on November 19, then it indicates you are negative for HIV completely. You have done a rapid test and an enzyme-linked immunosorbent assay (ELISA). The Western blot test is more confirmatory. Yes, that false negative concept is there, but if you are completely healthy and have no kind of clinical disease, then it is difficult to come false negative test results, but results also depend on the quality of the kit used and the person who reports that results (called technical error). The window period is one reason for a false negative, but it is a period of about one to two months after getting an infection, and in your case, it happened six months ago. So do not worry. But still, if you are worrying, then you can go for a Western blot test.

I hope this helps.

Kindly revert if there is any query.

Thank you.

Patient's Query

Thank you, doctor.

Can any other underlying disease which is not diagnosed affect my human immunodeficiency virus (HIV) test results? It is now 6 months and 22 days since the Elisa; is it conclusive?

Please help.

Thank you.

Hi,

Welcome back to icliniq.com.

There is no specific underlying disease that can interfere with test results. Technical errors and window period are the two possible reasons behind false negative test results. One more possibility of false negative test results is decreased host immunoglobulin production, such as in a common variable immunodeficiency and advanced Acquired immunodeficiency syndrome (AIDS).

I hope this helps.

Kindly revert if there is any query.

Thank you.

Medically reviewed byDr. Vinodhini J.

Published At June 23, 2020
Reviewed AtAugust 20, 2025

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