My father has been a diabetic patient for the past 20 years. Six months ago, he got affected by pulmonary tuberculosis and got administered with anti-TB drugs and insulin was administered in basal bolus regimen. Now both TB and diabetes are well under control. For the past one week, he takes only two drugs for TB, namely tablet Isokin 300 and tablet Pyzina 750 for TB, apart from tablet Glyciphage 500, tablet Cardivas CR 40, tablet Tazloc AM 80, and tablet Minipress XL 5 mg as suggested by the doctor.
But, for the past one month, I notice a change in his behavior. He has developed a sort of restlessness. He laughs childishly without caring about anything. He is developing an adamant attitude like for example, he took a huge quantity of food at one go, without heeding to our advice to eat slow and thereby a vomiting sensation developed. He is indifferent to everything now and seems to have no feeling of happiness, sadness, affection, or pain. He never listens to us and lives in his own world. This is more severe in the evenings and at night. His doctor mainly attributes this to stress and says he will be alright in due course when he entirely stops the TB drugs. Is this a side effect of the drugs or related to some other problem? Please help.
Welcome to icliniq.com.
I understand your concern.
From your description, I feel it is more than just stress. A simple thing such as stress cannot be attributed to these many complex symptoms. In my opinion, there are two possibilities which should be ruled out before calling it just stress.
1. Anti-TB drug induced psychosis: INH (Isoniazid) is a well-known cause of such a presentation, and the presence of INH in the treatment protocol makes me suspect it as the cause of his behavior changes.
2. Frontal lobe damage: Many of his actions are indicative of a disinhibitory behavior, which often arises from frontal lobe damage. I think a CT (computed tomography) scan should be done and the frontal lobe should be examined as his symptoms closely resemble those of frontal lobe damage.
I hope this helps you. Feel free to write back to me if you have more questions.
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