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My wife has a JAK2 positive myeloproliferative neoplasm with thrombocytosis. What does it mean?
Query: Hi doctor, My wife has a JAK2 (Janus kinase 2) positive myeloproliferative neoplasm with thrombocytosis, likely essential thrombocytosis. What does that mean? Does she have cancer or not? I need a fast and accurate answer. Does this mean she has cancer or not? What is life expectancy? Is there any ... Read Full »
Answer: Hi, Welcome to icliniq.com. I am a hematologist with 20 years of experience. I hope you and your family are doing well in this pandemic. JAK2 positive myeloproliferative neoplasms mean it is some cancer. JAK2 is a mutation in a gene that leads to unlimited production of platelets in your ca... Read Full »
Can you tell me more about the IDH2 gene mutation?
Query: Hello doctor, My preliminary diagnosis was essential thrombocythemia. They did genetic testing it showed JAK2 mutation (v617f) at about a 25 % allele burden. However, it also came back showing an IDH2 mutation. This tends to be found more in brain tumors and acute myeloid leukemia. The mutations fo... Read Full »
Answer: Hello, Welcome to icliniq.com. Thank you for your query. Elevated platelets are seen in iron deficiency anemia, post-splenectomy, acute blood loss, multicentric castleman disease, CML, 5q syndrome, primary myelofibrosis, rheumatologic, inflammation, drug-induced, and very rarely, it could be a part ... Read Full »