I have joint pain, fatigue, migraines, depression, and sometimes a burning sensation in my knees at night. What could be the reason?

Q. Can someone have uncomfortable joint pain without arthritis?

Answered by
Dr. K. Shanmuganandan
and medically reviewed by iCliniq medical review team.
This is a premium question & answer published on Mar 26, 2023 and last reviewed on: Apr 06, 2023

Hello doctor,

I am a 42-year-old female. I have joint pain (both hands, knees, and neck), fatigue, migraines, depression, and sometimes a burning sensation in my knees at night. I have increased stiffness and pain in the morning and settle throughout the day and the pain resumes at night. I took an Aimovig injection two months ago. I am currently taking Atorvastatin 20 mg daily, Vitamin D3 5000 IU one daily, Wellbutrin XL 150 mg 1 daily, and Sumatriptan 25 mg if needed. X-rays were taken and they were negative for arthritis. I consulted a rheumatologist and he told me that he was sure that I did not have arthritis. I asked him why would a 42-year-old have joint pain and he answered that it happens. Is this true, can someone suffer uncomfortable joint pain without having arthritis? If so are there any other explanations for the joint pain?



Welcome to icliniq.com.

I have read your query and understand your concern.

Yes, you are right, you may have joint pains without arthritis. There could be a few reasons for your joint pains.

1. Side effect of Atorvastatin.

2. Chronic fatigue syndrome

3. Due to Aimovig (Erenumab) injection.

Please do the following laboratory tests and follow up.

1. ESR (erythrocyte sedimentation rate).

2. CRP (C-reactive protein).

3. ANTI-CCP (anti-cyclic citrullinated peptide) antibody.

4. ANA (antinuclear antibodies).

5. Vitamin D levels.

Thank you.

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