Major Depressive Disorder

Major depressive disorder, also frequently called depression, is a mental health disorder characterized by a prolonged period of a depressive state. The patient will have symptoms like; feelings of sadness over a long period, frustration, lack of interest in work, school, and everyday activities, disturbance in sleep routine, constant tiredness, anxiety, loss of appetite, frequent suicidal thoughts or thoughts of death, etc. Depression, in its many forms, can affect children, teenagers, and adults. The treatment of depression usually includes medication, therapy, or a combination of both medication and therapy. According to research, these therapies may restore brain abnormalities related to depression.

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Why do I get so intimidated by others?

Query: Hi doctor, I am a 38-year-old male. I am married and I have a child. I have difficulty in sleeping at night. But I always feel sleepy. I forget things easily. I have low concentration and I am lethargic. I have confusion to take a decision. I have low self-esteem with low confidence. I feel like ...  Read Full »

Dr. Parth N. Nagda

Answer: Hi, Welcome to Your symptoms are typically seen in major depressive disorder. It is common to have it in 1 in 4 males and 1 in 8 females. It occurs due to reduced levels of certain neurotransmitters such as serotonin in the body. It reduces the stress-handling capacity of the brai...  Read Full »

How to deal with alternative anxiety phase and extreme mood swings?

Query: Hi doctor, I get in a depressive phase for a while and I cannot seem to get out of it and then I feel completely fine like nothing happened. So I did not tend to take any actions. But it is recently been affecting my personal and work life. I tend to not feel like myself. Currently, I am on Lame...  Read Full »

Dr. Parth N. Nagda

Answer: Hello, Welcome to What are your symptoms exactly? If they are of depression, then the treatment with SSRI (selective serotonin reuptake inhibitors) is ideally given for six months or so. The Lamez 25 (Lamotrigine) is just a mood stabilizer, if the psychiatrist is suspecting bipolar di...  Read Full »

How can Tramadol replace Ketamine in treating major depression?

Query: Hello doctor, My 19-year-old son is suffering from major depression and has been on at least four different medications, ECT and Ketamine treatments. ECT and the Ketamine seem to show the best results so far but are short-lived. And I hate to keep shocking his brain if this is not going to work (...  Read Full »

Dr. Parth N. Nagda

Answer: Hello, Welcome to Resistant or long-standing depression needs treatment with a mood stabilizer that has not been given the list on ongoing medicines. I would recommend that you add a mood stabilizer like Divalproex sodium or Lithium Carbonate. It will help hold the mood in place once ...  Read Full »

How to cope up with depressive thoughts caused after TB diagnosis?

Query: Hello doctor, I am a 22-year-old female. I weigh about 52 kg. So from the last one year, right after my graduation, I am at home as I was diagnosed with TB. So being at home I feel depressed. My mood changes every minute. My behavior from the last six months is irritating and arrogant. The people a...  Read Full »

Dr. Parth N. Nagda

Answer: Hello, Welcome to Your description and symptoms are typical of major depressive disorder. This happens very commonly, one in four women can have this at any point in their life. Due to any prolonged stresses, sometimes the stress handling capacity of the brain gets reduced due to the ...  Read Full »

What medication in the SNRI class works the best for major depression?

Query: Hello doctor, I need help for my 19-year-old son. He has tried SSRI's which did not work (Then we had the Gene testing done and it showed that he should not be on the one that he was on) and seemed to make him worse. He is now on an SNRI, the same one that his mother is on and that is not working ...  Read Full »

Dr. Parth N. Nagda

Answer: Hello, Welcome to Firstly sir, it is just a brief labelling to broadly differentiate classes, but many people who do not respond to one SSRI/SNRI, will do well with another drug of the same class, so cross switching between classes is also done. Among the SNRI, my personal experience...  Read Full »

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