Common "Connective Tissue Disease" queries answered by top doctors | iCliniq

Connective Tissue Disease

The disease of the structures connecting the body is known as connective tissue disease. In connective tissue disease, the body parts they connect are harmed, and the protein components (collagen and elastin) are inflamed. Connective tissue diseases can be of autoimmune origin, hereditary, environmental factors (UV radiation, toxic chemicals, and nutritional deficiency), or unknown causes. It includes scleroderma, rheumatoid arthritis, Churg-Strauss syndrome, polymyositis, systemic lupus erythematosus (SLE), microscopic polyangiitis, Wegener's granulomatosis, mixed and undifferentiated connective tissue diseases.

Recently Answered Questions Recently Answered Questions

All the answers published in this website are written by verified medical doctors, therapists and health experts. The Content has been moderated by iCliniq medical review team before publication. Post your medical clarifications on iCliniq by choosing the right specialty and get them answered. Your medical queries will be answered 24/7 by top doctors from iCliniq.

I have red, itchy rashes. Can a biopsy help diagnose?

Query: Hello doctor,I am a 43-year-old female, and I have had itchy, red, and burning rashes. It all started as a few bumps on my right arm, above my eyebrow, right upper nose area, all over the jaw and chin area, right chest, and upper back reacting badly to the sun, and it is getting worse. I have had a ...  Read Full »


Dr. Naval Mendiratta

Answer: Hello, Welcome to icliniq.com. The rashes that you are describing along with the biopsy findings can go in favor of a connective tissue disease. Although I would like to see the reports in detail, as you mentioned interface dermatitis, goes more in favor of lupus over dermatomyositis. But, we ...  Read Full »

Is a positive RNP test indicative of rheumatoid arthritis?

Query: Hi doctor, I have been diagnosed with RNP positive. I have dry eyes problem. Is RNP positive alone considered as RA? My ANA was negative and all other things negative. My eosinophils are 8.5% in my blood, and I am always suffering from col. I am on HCQS 200 and Defza 6 mg. Please help me.  Read Full »


Dr. Penchilaprasad Kandikattu

Answer: Hello, Welcome to icliniq.com. You may be suffering from mixed connective tissue disorder. But do not worry you may have to take above medications along with that you may take tablet Banocide forte 100 mg twice daily for three weeks. Avoid using plastic. Take plenty of fruits with vegetables. Use ...  Read Full »

What causes low back pain, joint pain, and fatigue with high ANA?

Query: Hello doctor,My ANA is 1:2560. I am having pain in the lower back, dry mouth, and joint pain in my hands. I feel very fatigued, and I have a history of celiac disease.  Read Full »


Dr. Nupoor Acharya

Answer: Hello,Welcome to icliniq.com.The symptoms you are describing are suggesting a connective tissue disease, most likely primary Sjogren's syndrome. It is an autoimmune disease that presents with dryness of the eyes, mouth, dental caries, fatigue, mild to severe joint pains, body aches, and sometimes ne...  Read Full »

What does severe fatigue with positive ANA test indicate?

Query: Hello doctor,I started to become very fatigued. My doctor sent me for some lab work and my ANA tested positive when a high membrane pattern of 1:1280. I have pain in my hands and back of my legs and the fatigue has continued since then. I also developed a bumpy rash on my abdomen. I was put on an an...  Read Full »


Dr. Puri Divya Inder

Answer: Hi,Welcome to icliniq.com.Your test suggests that you are suffering from a connective tissue disease. The symptoms may be nonspecific like you have fatigue, arthritis, rash, dry eyes, and mouth. It is advisable to do an extractable nuclear antigen (ENA) to reveal which particular antibodies are posi...  Read Full »

What could be the reason for arthritis with pale violet and gangrene in fingers?

Query: Hello doctor,My wife has arthritis and has become very weak over the last few months. Now she has a condition that is more or less like Raynaud's phenomenon. Her fingers are turning pale violet and one of the fingers had gangrene-like occurrences. Not only the hands but even the toes are experiencin...  Read Full »


Dr. Naval Mendiratta

Answer: Hello, Welcome to icliniq.com. You are right in saying that she has the symptoms of Raynaud's with digital gangrene which is on going. Arthritis, there are 50 variants of it and it is very important to distinguish which one she has as the management will differ for every arthritis. I would like to...  Read Full »

Are the results with ANA value 64 and ESR value 25 a cause of concern?

Query: Hi doctor, I have started to experience weird sensations around my body after my father died three years ago. I would often get sudden stabbing head pains, numbness in face, painful and sometimes stiff fingers especially, after waking up. More recently, I get heart palpitations, which force me to co...  Read Full »


Dr. Puri Divya Inder

Answer: Hi, Welcome to icliniq.com. I have seen all the reports (attachment removed to protect patient identity). This does not look like lupus. Lupus is a serious disease, which apart from other symptoms, can affect the kidneys and the brain. I agree that your ANA (antinuclear antibody) is positive, howeve...  Read Full »

Why does my wife have joint pain?

Query: Hi doctor, My wife has been suffering from joint pains for the past two days. She is 21 years old. We got married last month. Her symptoms are light and she also has headache.  Read Full »


Dr. Naresh Kumar M.

Answer: Hello, Welcome to icliniq.com. I had gone through the details you have posted. To know the diagnosis of joint pain I need to know some details. Which joints are most involved? Is there any swelling and tenderness? Is there severe pain on movement of involved joints? There are many causes for joint ...  Read Full »

I have been feeling sick and tired for the past six weeks. Kindly help.

Query: Hi doctor, I keep having these waves of feeling sick and tired with no energy for about six weeks now.  Read Full »


Dr. Murali Rayani

Answer: Hello, Welcome to icliniq.com. Feeling tired or sick may have lots of causes. More information from you may help in giving a diagnosis.  The causes could be:  The most common cause is anemia. Do a complete blood picture to rule it out. Record your temperature to check for a fever or an infection...  Read Full »

What does ANA positive in a blood test with joint pain indicate?

Query: Hi doctor, I recently had routine laboratory tests done ordered by my gynecologist. First time I had the SED test done. The rate was 35, so she ordered some other tests. Alpha globulin 1 result is 40, ANA test is positive, ANA titer is 1:40, ANA pattern nuclear, homogenous, and rheumatoid factor. I...  Read Full »


Dr. Nupoor Acharya

Answer: Hello, Welcome to icliniq.com. Your ESR (erythrocyte sedimentation rate) is a little high, and ANA (antinuclear antibodies) is positive. However, 1:40 is a very low titer. ANA positivity may be seen in different connective tissue diseases (CTD). A low titer positivity may also be seen in normal ...  Read Full »

ask-doctor-img Ask a Doctor Online

* Your first query consult is free!

Search for a Health Issue



Disclaimer: No content published on this website is intended to be a substitute for professional medical diagnosis, advice or treatment by a trained physician. Seek advice from your physician or other qualified healthcare providers with questions you may have regarding your symptoms and medical condition for a complete medical diagnosis. Do not delay or disregard seeking professional medical advice because of something you have read on this website. Read our Editorial Process to know how we create content for health articles and queries.