Recently Answered Questions
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Why does bone marrow aspiration and biopsy report differ?
Query: Hi doctor, Bone marrow aspiration twice showed hypercellular bone marrow with overgrowth of WBC and megakaryocytes with all stages of maturing including micro-megakaryocytes. But at the same time, the second BMA during bone marrow biopsy showed normocellular bone marrow. Is something like that possi... Read Full »
Dr. Goswami Parth Rajendragiri
Answer: Hi, Welcome to icliniq.com. You have not mentioned the age of the patient, peripheral smear, and CBC (complete blood count) findings. You mentioned that bone marrow was showing overgrowth of the WBC (white blood cells) and micro megakaryocytes. So, it is a myeloproliferative condition. Here, cli... Read Full »
Will quitting alcohol and cigarettes improve my blood tests?
Query: Hello doctor, I am suffering from hypertension since few years, and I am currently on medication Telmisartan. I am an alcoholic and smoker, and I smoke approximately 15 cigarettes a day for the last five years. My current CBC report suggests high RBC, hemoglobin, and PCV. Though it reduced slightly ... Read Full »
Dr. Goswami Parth Rajendragiri
Answer: Hi,Welcome to icliniq.com.I have gone through your attached reports (attachment removed to protect patient identity).The diagnosis is polycythemia. Polycythemia can be secondary or primary. Secondary polycythemia occurs because of hypoxia, which activates the oxygen sensor and more erythropoietin is... Read Full »
My wife has a JAK2 positive myeloproliferative neoplasm with thrombocytosis. What does it mean?
Query: Hi doctor, My wife has a JAK2 (Janus kinase 2) positive myeloproliferative neoplasm with thrombocytosis, likely essential thrombocytosis. What does that mean? Does she have cancer or not? I need a fast and accurate answer. Does this mean she has cancer or not? What is life expectancy? Is there any ... Read Full »
Answer: Hi, Welcome to icliniq.com. I am a hematologist with 20 years of experience. I hope you and your family are doing well in this pandemic. JAK2 positive myeloproliferative neoplasms mean it is some cancer. JAK2 is a mutation in a gene that leads to unlimited production of platelets in your ca... Read Full »
Is JAK2 mutation a life-threatening condition?
Query: Hi doctor, I understand that JAK2 myeloproliferative or myelodysplastic overlap disorder is life-threatening if it turns into an acute transformation. However, in your opinion, is the condition generally considered life-threatening when there has not yet been a severe transformation? That is when i... Read Full »
Answer: Hi, Welcome to icliniq.com. I have gone through your query. JAK2 mutations are severe conditions if they undergo an acute transformation. It means the cells in our body, especially the precursors of our blood cells (red blood cells, white blood cells, and platelets), start proliferating suddenly ... Read Full »
What causes an elevated vitamin B12 level without the use of supplements?
Query: Hello doctor, I had pain in my right lower back following playing basketball. I consulted a physiotherapist, and he suggested me do some blood work for inflammatory markers, and the results were normal. I also did complete blood count (CBC), liver function test (LFT), kidney function, cholesterol, C... Read Full »
Answer: Hello, Welcome to icliniq.com. Elevated vitamin B12 levels can be seen in certain blood-related conditions like myeloproliferative disorders. It may also be seen in some liver conditions. Since all the remaining values are normal, these conditions seem unlikely in your case. However, to be sur... Read Full »
Should I take Ruxolitinib for myeloproliferative neoplasm?
Query: Hello doctor,I am a 57-year-old female. I am suffering from myeloproliferative neoplasm. I have been prescribed Ruxolitinib 5 mg twice daily, which I have not started yet. Should I take this medication?Kindly help. Read Full »
Answer: Hello, Welcome to icliniq.com. Thank you for your query. I understand your concern. Myeloproliferative neoplasms (MPN) are a heterogeneous group of disorders of the hematopoietic stem cells. They can share a common genetic basis. From what you mentioned, it is unclear which type of MPN you are di... Read Full »
Is it necessary to monitor for MPN in case of slightly elevated RBC with DNA mutations?
Query: Hello doctor, For three years, my RBC has been slightly elevated (~4.9). My DNA results show a homozygous GG genotype for SNP rs12340895 of the JAK2 gene indicating greatly increased odds of developing JAK2 V617F-positive MPN. I have no symptoms and I am in good health. Should I see a hematologis... Read Full »
Answer: Hi, Welcome to icliniq.com. Based on your query, my opinion is as follows: Numerous DNA mutations are always present and it is difficult to monitor for any specific malignancy. However, speaking specifically, the mutation you have described can be seen in 50% of the normal population, which is very ... Read Full »
My blood test showed vitamin B12 level as six times higher than normal. What could be the cause?
Query: Hello doctor, I recently had a blood test and was found to have a B12 content nearly six times higher than 10 months ago of about 1700. I have been taking B12 supplements for about six months, which I have now stopped. Could the supplement (2000 mg/day) be the cause of the hike or is there an under... Read Full »
Dr. Goswami Parth Rajendragiri
Answer: Hello, Welcome to the icliniq.com. The very common cause for elevated B 12 is the B 12 supplement or injection intake. So in your case, high B 12 might be due to B 12 supplement intake. Hence it is advisable to stop B 12 supplement now. However, other causes also should be screened like myeloproli... Read Full »
What is myeloproliferative neoplasm overlap syndrome?
Query: Hi doctor, My relative has myelodysplastic syndrome or myeloproliferative neoplasm overlap syndromes. He was told that if the disorder takes an acute transformation, then it may be life-threatening. However, could you please tell me if there is some other way (or some other stage) in which the disor... Read Full »
Answer: Hi, Welcome to icliniq.com. Myelodysplastic syndrome or myeloproliferative neoplasm are a collection of disorders, singly or collectively called so. The life threat depends on chromosomal abnormalities, the number of blast cells (highly doubling cells), the number of lineages involved, and cytopen... Read Full »
Why is my platelet count raised without any symptoms?
Query: Hello doctor, Ten days back I checked my report. All reports are normal. Only platelets are 590000. I have no symptoms and no fever about that. Read Full »
Dr. Goswami Parth Rajendragiri
Answer: Hello, Welcome to icliniq.com. The increase in platelet count can be because of a primary cause like myeloproliferative neoplasm or secondary reactive cause. Secondary cause includes some inflammation, infection, hemorrhage or anemia-like condition. You can take a healthy diet with more vegetable ... Read Full »