Common "Papp-a" queries answered by top doctors | iCliniq

Papp-a

PAPP-A or PAPPA or pregnancy-associated plasma protein A is used in the prenatal screening of Down syndrome. Low level of this protein is used as a biochemical marker in prenatal testing.

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What do my dual test reports mean?

Query: Hi doctor, I just did a dual test. I am worried right now, please help. The report is as follows: Gestational age is 12 weeks and six days, crown-rump length 64.8 mm, nuchal translucency MoM 1.7 mm, nasal bone is seen, free beta-hCG 60.47 mIU/mL, PAPP-A 6020 mIU/mL. Method: ECLIA (fully automated el...  Read Full »


Dr. Sree Gouri. S. R

Answer: Hi, Welcome to icliniq.com. I can understand your concern. According to your test results (attachment removed to protect patient identity), negative factors are: PAPP-A (Pregnancy-associated plasma protein A) levels are elevated. Beta HCG (Human chorionic gonadotropin) levels are low. Positi...  Read Full »

The NT scan revealed possible gastroschisis. Please help.

Query: Hello doctor, I am 12 weeks one day pregnant. I went in for my NT scan today and they said it has possible gastroschisis and I am honestly just so worried. I have a check up in the next two weeks but I am just curious to know if it could be normal that the intestines still are not inside the fetus? ...  Read Full »


Dr. Uzma Arqam

Answer: Hi, Welcome to icliniq.com Normally intestine is outside body of the fetus from 6 to 10 weeks of gestation is known as an intestinal hernia. Around 11 weeks it should be inside the body of the fetus. If you have been irregular periods there could be a discrepancy of dates between the scan and your ...  Read Full »

My double marker test report is abnormal. Is my baby healthy?

Query: Hi doctor, I had my nuchal translucency scan and double marker blood tests taken a few days ago. I am worried because my NT scan reports are normal, but my double marker test report shows a high risk for trisomy 21. All reports are attached for your guidance and suggestions. Kindly help.  Read Full »


Dr. Balakrishnan R

Answer: Hi, Welcome to icliniq.com. I hope you are doing well. I read your query, and I can understand your concern. From your history and reports (attachments removed to protect patient's identity), I gather that you are 33 years old, which is a low-risk age, and there are no other risk factors. Previousl...  Read Full »

What does PAPP-A screen test of 1.9 and hCG level of 65.6 indicate?

Query: Hi doctor, My wife has done a PAPP-A screen test and results are 1.9 and hCG level 65.6. She is 12 weeks pregnant. Please advise regarding the same. Thank you.  Read Full »


Dr. Sameer Kumar

Answer: Hello, Welcome to icliniq.com. You need to attach the complete report issued by the laboratory. Important thing is the graph and the MoM (multiple of the median) values which have been calculated as per the gestational age. The risk is calculated accordingly. In case of Down's syndrome, there is ...  Read Full »

I am 29 years old and pregnant for the second time. Please interpret my double marker test results.

Query: Hello doctor, My age is 29, and I am pregnant for the second time. I am 11 weeks and 6 days pregnant. Recently, my doctor advised me of a double marker test. The PAPP-A is 0.48 MoM, and FB-hCG is 0.33 MoM. The calculated risk for trisomy 13/19 is 1:3142 and shows low risk, and the calculated risk fo...  Read Full »


Dr. Uzma Arqam

Answer: Hello, Welcome to icliniq.com. I thoroughly read your query and understand your concern. Biochemistry (two hormones levels), nuchal translucency, family history, and female age all combine to calculate risk. It would be better if you send me reports of the same and some detailed history. As you s...  Read Full »

What does my double marker blood test indicate?

Query: Hi doctor, I am 12 weeks 5 days pregnant. I got my NT scan and double marker blood test results. NT value 1.1 mm, free b-hCG 1.52 MOM, PAPP-A 0.37 MOM, trisomy 21+NT risk 1:1132, trisomy 21 1:169, trisomy 13/18+NT. In urine culture, there is no significant growth observed after 48 hours. I am curren...  Read Full »


Dr. Mavani Jimesh Himatbhai

Answer: Hello, Welcome to icliniq.com. I have seen the report completely (attachment removed to protect patient identity). Your report is normal and there is no need to worry. If you want a detailed explanation about the report, then here you go. There are some genetic syndromes, which are happening worl...  Read Full »

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