Q. Did I get an intermittent twitch in my legs, calves, and thighs because of my asymmetrical thighs?

Answered by
Dr. Aida Abaz Quka
and medically reviewed by iCliniq medical review team.
This is a premium question & answer published on Mar 23, 2022

Hi doctor,

I have an intermittent twitch in both legs, calves, and thighs. I think it happens when I am anxious or stressed at work. But I am not sure how long I had the twitches and, it worsens if I focus on it. I searched online about ALS and just also noticed that one of my thighs is 1.5 to 2 cm smaller than other, so even more concerned based on atrophy in ALS. I have no weakness. Recently, I had a health check-up and, all the reflex is good and, blood levels are clear. Currently, I am taking medications for asthma. Kindly help.



Welcome to

I understand your concern. I would like to explain that your symptoms could be related to anxiety or benign fasciculation syndrome. Anyway, I suggest the following:

1) Check vitamin D, vitamin B12 plasma levels, and thyroid hormone levels for thyroid gland dysfunction.

2) Measure with a meter that both the thighs in the same level to determine if there is any significant difference.

You should know that all bodies are asymmetrical, and this is not a disease. If asymmetrical legs are associated with weakness in the thinner leg, I also suggest nerve conduction studies should be done.

Kindly revert in case of further queries.

Thank you.

Hi doctor,

Thank you for the reply. I have no weakness in any leg or body but my thigh circumference is around 1 to 2 cm difference. The mid point of the thigh may be 1.5 to 2 cm (my left thigh is the thinnest). I have seen that in motor neuron disease, atrophy comes before weakness, but I am not sure. So, I am worried. Kindly help.



Welcome back to

I understand your concern. Usually, the leg thinning starts distally in the calves, not in the thighs, and it is symmetrical in ALS (amyotrophic lateral sclerosis). A pinched nerve can cause asymmetrical thinning in the thighs. On the other hand, thinning goes parallel to muscle weakness. For this reason, I suggest performing nerve conduction studies just to put your mind to ease, as, in my opinion, nothing serious seems to be going on.

I hope you understand.

Kindly revert in case of further queries.

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