iCliniq logo

Ask a Doctor Online Now

HomeAnswersOphthalmology (Eye Care)neuromyelitis opticaI tested for neuromyelitis optica, and anti-AQP4 was negative.

What could cause the burning sensation and pain in my eyes even though I am tested negative for anti-AQP4?

The following is an actual conversation between an iCliniq user and a doctor that has been reviewed and published as a Premium Q&A.

Medically reviewed by

iCliniq medical review team

Published At December 2, 2022
Reviewed AtOctober 10, 2023

Patient's Query


I am a 27-year-old and was tested for neuromyelitis optica because I have symptoms of eye pain, burning sensation in my eye, and sometimes throbbing. I also have large optic nerve cupping, blurred peripheral vision, and fatigue. However, test results were negative for anti-AQP4. In addition, this test did not detect abnormal levels of anti-AQP4 antibodies.

Answered by Dr. Rahul Vaswani


Welcome to icliniq.com.

I understand your concern. Though the detection of anti-AQP4 is one of the supportive criteria to diagnose Devic's disease (neuromyelitis optica), there are other criteria also. Absolute criteria include optic neuritis and acute myelitis. In addition, brain magnetic resonance imaging does not meet the criteria for multiple sclerosis at disease onset. Spinal cord MRI with continuous T2-weighted signal abnormality extending over three or more vertebral segments, indicating a relatively large lesion in the spinal cord. NMO-IgG seropositive status (The NMO-IgG test checks the existence of antibodies against the aquaporin 4 antigen). I hope it will work.

Same symptoms don't mean you have the same problem. Consult a doctor now!

Dr. Rahul Vaswani
Dr. Rahul Vaswani

Ophthalmology (Eye Care)

Community Banner Mobile
By subscribing, I agree to iCliniq's Terms & Privacy Policy.

Ask your health query to a doctor online

Ophthalmology (Eye Care)

*guaranteed answer within 4 hours

Disclaimer: No content published on this website is intended to be a substitute for professional medical diagnosis, advice or treatment by a trained physician. Seek advice from your physician or other qualified healthcare providers with questions you may have regarding your symptoms and medical condition for a complete medical diagnosis. Do not delay or disregard seeking professional medical advice because of something you have read on this website. Read our Editorial Process to know how we create content for health articles and queries.

This website uses cookies to ensure you get the best experience on our website. iCliniq privacy policy