Q. What could cause the burning sensation and pain in my eyes even though I am tested negative for anti-AQP4?

Answered by
Dr. Rahul Vaswani
and medically reviewed by iCliniq medical review team.
This is a premium question & answer published on Dec 02, 2022 and last reviewed on: Dec 23, 2022


I am a 27-year-old and was tested for neuromyelitis optica because I have symptoms of eye pain, burning sensation in my eye, and sometimes throbbing. I also have large optic nerve cupping, blurred peripheral vision, and fatigue. However, test results were negative for anti-AQP4. In addition, this test did not detect abnormal levels of anti-AQP4 antibodies.



Welcome to

I understand your concern.

Though the detection of anti-AQP4 is one of the supportive criteria to diagnose Devic's disease (neuromyelitis optica), there are other criteria also.

Absolute criteria include optic neuritis and acute myelitis. In addition, brain magnetic resonance imaging does not meet the criteria for multiple sclerosis at disease onset.

Spinal cord MRI with continuous T2-weighted signal abnormality extending over three or more vertebral segments, indicating a relatively large lesion in the spinal cord. NMO-IgG seropositive status (The NMO-IgG test checks the existence of antibodies against the aquaporin 4 antigen).

I hope it will work.

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