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HomeAnswersOphthalmology (Eye Care)neuromyelitis opticaI tested for neuromyelitis optica, and anti-AQP4 was negative.

What could cause the burning sensation and pain in my eyes even though I am tested negative for anti-AQP4?

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Medically reviewed by

iCliniq medical review team

Published At December 2, 2022
Reviewed AtOctober 10, 2023

Patient's Query

Hello,

I am a 27-year-old and was tested for neuromyelitis optica because I have symptoms of eye pain, burning sensation in my eye, and sometimes throbbing. I also have large optic nerve cupping, blurred peripheral vision, and fatigue. However, test results were negative for anti-AQP4. In addition, this test did not detect abnormal levels of anti-AQP4 antibodies.

Answered by Dr. Rahul Vaswani

Hi,

Welcome to icliniq.com.

I understand your concern. Though the detection of anti-AQP4 is one of the supportive criteria to diagnose Devic's disease (neuromyelitis optica), there are other criteria also. Absolute criteria include optic neuritis and acute myelitis. In addition, brain magnetic resonance imaging does not meet the criteria for multiple sclerosis at disease onset. Spinal cord MRI with continuous T2-weighted signal abnormality extending over three or more vertebral segments, indicating a relatively large lesion in the spinal cord. NMO-IgG seropositive status (The NMO-IgG test checks the existence of antibodies against the aquaporin 4 antigen). I hope it will work.

Same symptoms don't mean you have the same problem. Consult a doctor now!

Dr. Rahul Vaswani
Dr. Rahul Vaswani

Ophthalmology (Eye Care)

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