What is the difference between 0.018 and 0.022 orthodontic brackets?

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The difference between both the size brackets is the slots in which the wires are held on to in the brackets. There are minor differences in the treatment mechanics between the both. 0.022 brackets can hold larger wires in the slots. The larger slot size can sometimes be more helpful in managing the spaces and maintaining good control of tooth positions. Also, 0.018 slots size will have smaller size wires that apply lesser forces, thus slightly more comfortable during space closure. However, effectively it will not make much difference in treatment quality and total time. The final say in the bracket size depends on what your orthodontist is comfortable using. Both give good results in the end and are not very different in comfort.