HomeAnswersObstetrics and Gynecologyovulatory dysfunctionI have PCOS and cannot ovulate even after taking tablets Metformin and Letrozole. Please help.

Why am I unable to ovulate even after taking Metformin and Letrozole for PCOS?

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The following is an actual conversation between an iCliniq user and a doctor that has been reviewed and published as a Premium Q&A.

Medically reviewed by

iCliniq medical review team

Published At February 4, 2023
Reviewed AtFebruary 4, 2023

Patient's Query

Hello doctor,

I have PCOS. Currently, I am on tablet Metformin and Letrozole. Still, I am not ovulating. My LH levels are 13 IU/L, and my FSH is 4.9 IU/L. Please help.

Hello,

Welcome to icliniq.com.

I read your query and can understand your concern.

I can understand that you are worked up about not ovulating despite being on multiple ovulation induction medicines. Please answer the following questions.

1. Have you got an ultrasound done?

2. Did the ultrasound show that the follicle is growing?

3. Since when are you taking these medicines?

Hope this helps.

Thank you and take care.

Patient's Query

Hello doctor,

Thank you for your reply.

My follicles grow up to 25 mm but are not rupturing. Also, my endometrial thickness is 4 mm on the 20th day, and my LH levels are high. What should I do now?

Hello,

Welcome to icliniq.com.

I read your query and can understand your concern.

Have you been given HUCOG (human chorionic gonadotropin) injections when your follicle reaches the appropriate size?

1. Your high LH levels are suggestive that your PCOS (polycystic ovarian syndrome) is not under control. You could stop the ovulation induction for three months and try oral contraceptive pills to reduce the LH levels.

2. You could use ovulation induction with injections instead of tablets. This depends on how many cycles you have used the tablets for.

I think you should try oral contraceptive pills and then restart ovulation induction. However, please consult a physician, discuss with them and start taking the medications with their consent.

Hope this helps.

Thank you and take care.

Same symptoms don't mean you have the same problem. Consult a doctor now!

Dr. Manwani Saloni Dilip
Dr. Manwani Saloni Dilip

Obstetrics and Gynecology

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