Q. What are the side effects of long-term usage of tablet Cyproterone and Ethinyl Estradiol?

Answered by
Dr. Uzma Arqam
and medically reviewed by iCliniq medical review team.
This is a premium question & answer published on Jan 25, 2023

Hi doctor,

I have PCOS, and I am suffering from severe acne problems due to it. I took tablet Cyproterone and Ethinyl Estradiol for nine months, which resulted in a significant reduction in acne. It has been a year since I stopped taking the medication, and again acne problems have arisen. Does tablet Cyproterone and Ethinyl Estradiol have serious side effects, which might continue in the long run if I start taking them again?

Please advise.



Welcome to

Tablet Cyproterone and Ethinyl Estradiol are for patients with polycystic ovaries having acne and abnormal hair growth. If you are not having any benefit, it may be your body is not responding to it, so it is better to stop it now for some time and check the difference. You can have natural remedies for acne and hair growth, like a medicated mud mask. It is really nice for acne skin. It keeps skin dry and do not use oily products on it. Also, tomato massage will also clear oil from your skin.

Check if any product you are using does not suit your skin. Serious side effects on long-term use of oral contraceptives are always there, like abnormally irregular cycles, mood variations, clot formation means venous thromboembolism, stroke, high blood pressure, migraine, endometrial and breast cancer, etc. Hormonal treatment on long-term use having side effects, and every individual female gets its own side effects.

I advise you to do the following steps:

  • Have exercise for normal BMI (body mass index).
  • Follow a healthy diet with less salt, oil, sugar, and spice.
  • Have recreational activities for better mental health.

Thank you.

Was this answer helpful?


Same symptoms doesn’t mean you have the same problem. Consult a doctor now!

Related Questions:
Will PCOD cause an increase in weight and absence of ovulation after abortion?

Not to mention I am getting terrible acne now and the same when IUD was inserted ... And all other symptoms such as acne, painful intercourse, weight gain are seen in PCOD ...   Read full

Acne - Causes, Types, Home Remedies and Treatment Strategy

Many cosmetic procedures are available to provide clear and acne-free skin ... We all would have come across various advertisements for products aiming to provide acne-free, smooth skin in our da...   Read full

Am I taking the right homeopathy medicine for PCOD?

Hello doctor, I am taking Testosterone 30 to reduce testosterone as I am a PCOD patient but the pharmacist told me that it increases testosterone ... I have taken contraceptives, Metformin and ayurveda ...   Read full

Also Read Answers From:

ideaComprehensive Medical Second Opinion.Submit your Case

Also Read

H3N2v Influenza - Treatment and Prevention
Management and prevention of an Influenza A virus variant include various treatment options and measures. The below arti...  Read more»
Flu A - Symptoms, Causes, Diagnosis, Treatment and Prevention
The flu, or influenza, is a contagious viral infection that attacks the respiratory system. Flu A and B viruses are resp...  Read more»
H3N2v Influenza: Symptoms, Diagnosis, and Treatment
The H3N2v is a non-human influenza virus seen in pigs and can cause human infection. To know more, read the article belo...  Read more»

Ask your health query to a doctor online?

Ask an Obstetrician & Gynaecologist Now

* guaranteed answer within 4 hours.

Disclaimer: No content published on this website is intended to be a substitute for professional medical diagnosis, advice or treatment by a trained physician. Seek advice from your physician or other qualified healthcare providers with questions you may have regarding your symptoms and medical condition for a complete medical diagnosis. Do not delay or disregard seeking professional medical advice because of something you have read on this website. Read our Editorial Process to know how we create content for health articles and queries.