HomeAnswersInternal MedicinephentermineCan Cymbalta and Phentermine be used together for weight loss?

Can I take Phentermine along with Cymbalta?

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Published At June 7, 2016
Reviewed AtJuly 7, 2023

Patient's Query

Hi doctor,

I take Cymbalta 60 mg for depression and Trazodone 100 mg for sleep. Can I take Phentermine for weight loss without problems of serotonin syndrome?

Hi,

Welcome to iCliniq.com. Phentermine is a medication that is typically used for a short period of time, usually a few weeks, as an adjunctive treatment for weight reduction in patients with an initial body mass index (BMI) equal to or greater than 30 kg/m². Cymbalta, which contains the active ingredient duloxetine, has a serious interaction with Phentermine. When taken together, they can increase the toxicity of each other and pose a potential risk for serious or life-threatening interactions. Additionally, there is a risk of developing serotonin syndrome, which is a condition caused by excessive levels of serotonin in the body and can be life-threatening. Therefore, based on these interactions and risks, I would not recommend the simultaneous use of Cymbalta and Phentermine. Please let me know if you have any further questions or concerns.

Same symptoms don't mean you have the same problem. Consult a doctor now!

Dr. Srivastava, Sumit
Dr. Srivastava, Sumit

Internal Medicine

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