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Q. Can AST/ALT ratio of 2. 2 be due to fibrosis or cirrhosis of the liver?

Answered by
Dr. Utkarsh Sharma
and medically reviewed by Dr. Preetha J
This is a premium question & answer published on Nov 30, 2021

Hello doctor,

I recently had a blood draw at home by a visiting nurse for a life insurance application. AST (aspartate aminotransferase)/ALT (alanine aminotransferase) ratio came back high at 2.2. However, all other levels of my blood report are normal. AST is 13, and ALT is 6, so neither level is elevated. In online, it is indicated that this could be fibrosis or cirrhosis of the liver, but I cannot find much info regarding an isolated high AST/ALT ratio. Can you assist, please? Is this cause for concern warranting further testing? I have no other health conditions. I drink occasionally but not excessively (0-4 drinks per week). I drank more back in my younger age, 10 years ago but have never been an alcoholic. This blood test did not require fasting, and I had 2-3 drinks the night before the blood test. Is that the cause? I am currently taking multivitamins. Thank you.

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Hello,

Welcome to icliniq.com.

I understand your concern and will help you regarding it.

ALT/AST ratio can provide information about cirrhosis/liver damage but in proper context. These results are often interpreted in association with ultrasonography and other liver function tests. In your case, both the values are within normal limits, and this ratio is not relevant.

I believe you do not have any clinical symptoms like jaundice or abdominal pain.

Your drinking habit, as you have been told, is not likely to cause severe liver damage. Just take care of your nutrition and workouts. No further testing is required.

Take care and all the best.


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