Q. Can a second pregnancy be difficult for an Rh-negative mother?

Answered by
Dr. Mavani Jimesh Himatbhai
and medically reviewed by iCliniq medical review team.
This is a premium question & answer published on Sep 30, 2022

Hello doctor,

My sister is five months pregnant. She had her anatomy scan recently, and she was told that baby is in between 1 to 3 percentile, and there is a problem with the placenta (they suspect the baby is not getting enough oxygen and nutrition). The genetic test they did before (harmony test) did not show any genetic disorder. Doctors told her they would check the growth of the baby in two weeks. Meanwhile, they did amniocentesis to confirm baby does not have a genetic disorder, and the results are pending. She was told that in such cases, the baby is so small she might die in the womb, which puts my sister's life at risk as well. Because my sister is Rh negative, and the baby is most probably positive (her husband is positive and does not have anyone Rh negative in his family). She was given an injection for Rh incompatibility. Currently, she is on Aspirin. My sister used IVF to become pregnant.

My questions are:

1) What are the chances of my sister dying if the baby dies in her womb?

2) If the baby shows growth after two weeks scan, what are the chances of being born with a neural or motor disorder?



Welcome to

If your sister had been pregnant previously, then whether she had taken an injection for Rh comparability previously or not? What is her blood pressure now? What are ultrasound reports which were showing placental problems?

A problem for your sister if the baby dies in the womb is mostly less if the reports are normal, but the possibility cannot be ruled out. The baby having neural or motor problems cannot be ruled out completely, even if everything is found to be normal. Amniocentesis and all tests are done to find out this.

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