Dr. Anshul Varshney
Internal Medicine
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Patient's Query
Hello doctor,
My son is 19 years old and has Pitt Hopkins syndrome plus many other diagnoses. Five years ago, he started to have partial seizures that would end up going into generalized seizures. He has a long history of medical issues. However, his liver enzymes went up recently the past couple of days, and he is on Depakote sprinkles at one capsule at 125 mg in the morning and two capsules in the evening (which have stopped his seizure activity). He is also on Sertraline 100 mg and a half tablet of Olanzapine for cyclical vomiting. His doctors know what is going on and monitoring his bloodwork, but I am freaking out inside. Should I be freaking out? Does this mean liver failure? The doctors have not said much to ease my mind. It is hard to stay calm when waiting for the next move. Also, what other medications can he take other than Depokate without hurting his liver?
Hi,
Welcome to Icliniq.com.
These anti-epileptic drugs, as well as anti-depressants like Sertraline and Olanzapine, are known to cause liver dysfunction. So we need to be sure that these drugs are the culprit or some other cause is there.
I would recommend testing for Hepatitis B and C with an ultrasound abdomen. If the reports are normal, then the offending drugs would need to be stopped with replacement with safer alternatives.
I hope this helps.
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Internal Medicine
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