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I have read your query and can understand it.
ALP (Alkaline phosphatases) are a group of isoenzymes located on the outer layer of the cell membrane. The normal serum alkaline phosphatase consists of many distinct isoenzymes found in the liver, bone, placenta, and less commonly, in the small intestine.
The majority of alkaline phosphatase in serum (more than 80 %) is released from the liver and bone, and small amounts are from the intestine.
Following are the physiological conditions that can cause fluctuation in the value of the alkaline phosphatase enzymes without any obvious clinical diseases;
1) Patients over age 60 can have a mildly elevated alkaline phosphatase (which is one to one and a half times normal).
2) Individuals with blood types O and B can have an elevation of the serum alkaline phosphatase after eating a fatty meal, due to the influx of intestinal alkaline phosphatase into the blood.
3) It is also elevated in children and adolescents undergoing rapid bone growth because of bone alkaline phosphatase and in late normal pregnancies due to the influx of placental alkaline phosphatase.
Following are the ways to differentiate the source of alkaline phosphatase in case the value of alkaline phosphatase increases more than the upper limit range of the laboratory value;
1) If the elevated serum alkaline phosphatase is associated with deranged liver enzymes and bilirubin levels, then most likely the elevated alkaline phosphatase is of liver origin.
2) If the elevated serum alkaline phosphatase is the only abnormal finding in an apparently healthy person, or if the degree of elevation is higher than expected, identification of the source of elevated isoenzymes is helpful, which is done by fractionation of the alkaline phosphatase by electrophoresis (a laboratory method used to separate the DNA, RNA and proteins based on their size and electrical charge).
3) Other conditions that cause elevations of the alkaline phosphatase include Hodgkin's disease, diabetes, hyperthyroidism, congestive heart failure, amyloidosis, and inflammatory bowel disease. These help the clinician to correlate with the value of alkaline phosphatase based on the available medical history, other lab tests, imaging tests and diagnose the patient's condition.
I hope this helps.
Please revert with the laboratory report to interpret it better.