Tpha

Treponema pallidum hemagglutination is commonly known as TPHA. It is a diagnostic test that is used to determine the dissolved amount of antibodies in the serum sample against syphilis. This diagnostic test is used to diagnose Treponema pallidum infection, screen sexually transmitted diseases, and monitor the treatment of syphilis.

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Why is my test still reactive even after taking treatment for syphilis?

Query: Hi doctor, I am a 37 year old married female. Five years ago, I got a job offer in abroad. When I had a medical checkup, I was found to be positive for VDRL and TPHA reactive. But, my husband's result was nonreactive. I took medicine as advised by my doctor. Now, when I went for a checkup, again t...  Read Full »


Dr. Sagar Ramesh Makode

Answer: Hello, Welcome to icliniq.com. Firstly, VDRL (venereal research laboratory test) test usually becomes negative after successful treatment. However, TPHA - Treponema pallidum hemagglutination assay will remain positive throughout life. Positive TPHA just indicates that you have developed antibodies ...  Read Full »

I am concerned about my reactive TPHA result. Does it indicate STD?

Query: Hello doctor, In a routine VDRL test, I tested positive. We checked for HIV and syphilis. HIV was negative, while the TPH test was reactive. I underwent a therapy of penicillin two shots before ten months, one the next month and one more the following month with three weeks gap between each. I r...  Read Full »


Dr. Muhammad Zubayer Alam

Answer: Hi, Welcome to icliniq.com. I can understand your concern. According to your statement you have recently done TPHA (treponema pallidum hemagglutination assay) test and shown reactive (1:80). A reactive TPHA test most likely indicates infection by T.Pallidum but is not sufficient to determine dise...  Read Full »

Are STI tests on day 42 conclusive or do I require further testing?

Query: Hello doctor, I took the following STI tests on day 42 post a possible exposure and the reports show the following: HIV DUO (4th Gen) (CMIA) - Non Reactive (0.16) Syphilis Antibodies (Treponema) (EIA) - Negative (0.64) TPHA - Negative RPR - Non-Reactive HSV 1 & 2 - IgM antibody (EIA) - Negative ...  Read Full »


Dr. Sushil Kakkar

Answer: Hello, Welcome to icliniq.com.  I have gone through your query and I have noted your concern. Tests for HIV (4th generation - HIV DUO), chlamydia and syphilis (antibody test and TPHA) are conclusive at day 42, whereas the tests for herpes genitalis need to be repeated for IgG at 12 weeks for a conc...  Read Full »

Should I go for treponemal test three years after sexual contact?

Query: Hi doctor, I have an STD question and hope to have an STD specialist doctor to assist me. I had a sexual contact three years ago and only last month I went for (VDRL nontreponemal test) and is negative. I have read online that after several years or after sometime usually, the result can be negativ...  Read Full »


Dr. Sushil Kakkar

Answer: Hello, Welcome to icliniq.com. Yes, sometimes many years after an infection with Treponema pallidum, VDRL may turn negative. TPHA (Treponema pallidum hemagglutination) or FTA ABS (fluorescent treponemal antibody absorption test) would be confirmatory in that case. You may take this test. Syphilis...  Read Full »

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