Q. What kind of mitochondrial poisoning can stay in body for longer period?

Answered by
Dr. Arul Amuthan
and medically reviewed by iCliniq medical review team.
This is a premium question & answer published on Apr 23, 2016 and last reviewed on: Feb 10, 2020

Hello doctor,

Do you know what kind of mitochondrial poison can stay in the body for more than five years? I have a patient with symptoms which looks like a mild mitochondrial poisoning for the past five years. There are only few mitochondrial poisons. So, do you think any one of them can stay in the body for such a long period?



Welcome to icliniq.com.

  • Usually the mitochondrial toxicity (poisoning) occurs due to some natural toxins from animals and plants or synthetic.
  • In current days, the mitochondrial toxicity is majorly due to synthetic chemicals as human destroyed many toxic plants and animals in the living place.
  • The toxin may either inhibit electron transport in mitochondria or uncouple the oxidative phosphorylation reaction cascade or inhibits oxidative phosphorylation.
  • Whatever the mechanisms, the mitochondrial toxins can either kill the person as early as possible or person will not die if he escapes the death immediately. The physiological basis for the death is oxygen deprivation or unable to utilize oxygen by the body.
  • In my knowledge, there is no poison which can stay in the body (in mitochondria) for more than five years. If it could not kill the person immediately that means the given dose is low, then the drug gradually get excreted from the body.
  • The time for its excretion, disposal from body, is based on its chemical nature. No such toxins available to stay for more than five years.
  • I think there is one more possibility for the chronic mitochondrial symptoms. The toxin may initially damage mitochondrial DNAs and then gets excreted out of the body few years ago.
  • The genetic damage might have lead to mutation, which is alteration in DNA pattern. This may lead to the permanent damage of mitochondria, thus having persistent symptoms. Such drugs and chemicals are called as hit and run drugs.
  • In such cases, the drug has been already excreted out, thus cannot be detected from the body. But, the damage or chemical effect persists.
  • The mitochondrial DNA damage can be diagnosed through biotechnological methods, for which patient needs to give a small piece of (biopsy) muscle. This is the good idea to subject the patient for laboratory diagnosis for mitochondrial DNA damages.

For further information consult a pharmacologist online --> https://www.icliniq.com/ask-a-doctor-online/pharmacologist

Was this answer helpful?


Also Read Answers From:

Comprehensive Medical Second Opinion.Submit your Case

Related Questions & Answers

I have throat inflammation after drinking phenyl. What shall I do now?

Query: Hi doctor, I drank about 5 mL of white phenyl disinfectant. Following which I had a headache and took Allegra and Avil tablet. There is inflammation in my throat and ear. Today, I took Pantos tablet, Sucralfate and Oxetacaine suspension and Ultracet. What shall I do now?  Read Full »

How can we prevent tooth decay and say about the toxic things we touch everyday?

Query: Hi doctor, How can we prevent tooth decay? Please explain about the toxic things that we use every day and say a few words regarding healing tonics.  Read Full »

Also Read

I get twitches on my calves, shoulders, and head after getting the Novavax COVID vaccine. Please help.
Hello doctor, I got the Novavax COVID vaccine. Since I had the vaccine, I had bad arm pain. But the scary thing that ha...  Read more»
It hurts when I push above my left breast bone. Please help.
Hi doctor, I have been having some chest pain issues. When I push above my left breast bone it hurts in only one spot. ...  Read more»
Bird Flu (Avian Influenza) - Causes, Symptoms, Mortality Rate, and Treatment
Bird flu or avian influenza is a viral infection that spreads among birds and can affect humans rarely. Read the article...  Read more»

Ask your health query to a doctor online?

Ask a Pharmacologist Now

* guaranteed answer within 4 hours.

Disclaimer: All health Q&As published on this website are not intended to be a substitute for professional medical diagnosis, advice or treatment by a trained physician. Seek the advice from your physician or other qualified health-care providers with questions you may have regarding your symptoms and medical condition for a complete medical diagnosis. Do not delay or disregard seeking professional medical advice because of something you have read on this website.