How Does Burkitt Lymphoma Manifest Itself?
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Burkitt Lymphoma - Signs, Symptoms, Diagnosis, and Treatment

Published on Aug 29, 2022 and last reviewed on Mar 09, 2023   -  4 min read


Burkitt lymphoma is a type of non-Hodgkin’s lymphoma (NHL) and is a fast-growing tumor. To learn about this tumor, read the below article.

An Introduction:

The lymphatic system is one of the essential human body systems. This system has several lymph nodes at different body sites connected via tubes. These tubes, together with lymph nodes, are called the lymphatic system. The lymphatic system is responsible for the flow of a clear fluid called lymph. This clear liquid consists of two types of lymphatic cells: B lymphocytes and T lymphocytes. These are nothing but different white blood cells that fight infections if present. White blood cells are simply known to be the police force of the body. The function of B lymphocytes and T lymphocytes is to kill infectious organisms, but their role might vary slightly from each other.

What Is Burkitt Lymphoma?

Non-Hodgkin's lymphoma is a fast-growing type of cancer of the lymphatic system where abnormal amounts of incomplete WBC (white blood cells) are produced. When this happens, these WBC are accumulated on different body parts. Burkitt lymphoma is a type of non-Hodgkin's lymphoma that affects the B lymphocytes. Hence, it is also called B-cell lymphoma. This cancer is a fast-growing type of cancer, and it has to be treated as soon as the diagnosis is made to prolong the lifespan of the individual.

What Are the Types of Burkitt Lymphoma?

The world health organization (WHO) classified Burkitt lymphoma into the following three types, namely -

  1. Endemic Burkitt Lymphoma (African): This type of Burkitt lymphoma is prevalent among the children of Africa. The children affected are between the ages of four and seven. It affects boys more than girls.

  2. Sporadic Burkitt Lymphoma (Non-African): This type of Burkitt lymphoma is a type that affects people globally other than in Africa. About one to two percent of lymphoma cases are Burkitt lymphoma worldwide. About 40% of pediatric lymphoma cases are Burkitt lymphoma in the US and western Europe.

  3. Immunodeficiency Associated Burkitt Lymphoma: This type of Burkitt lymphoma occurs in severely immunocompromised people. It is widespread in people with HIV (human immunodeficiency virus) infection as this virus makes the person immunocompromised. This type of Burkitt lymphoma can also be seen in people who have congenital immune disorders or if a person intakes immunosuppressant drugs for an extended period of time.

What Are the Signs and Symptoms Associated With Burkitt Lymphoma?

The symptoms of Burkitt lymphoma depend upon the type of Burkitt lymphoma. However, in cases of endemic Burkitt lymphoma, the following are the standard features seen:

In cases of sporadic Burkitt lymphoma or immunodeficiency Burkitt lymphoma, the following are the common signs and symptoms:

  • The tumor often starts as a huge mass in the abdomen and can spread to the liver, spleen, and bone marrow.

  • This type of Burkitt lymphoma can also start from the ovaries or testes and spread to other vital structures like the brain and spinal fluid.

Some of the common symptoms of Burkitt lymphoma are discussed below -

  • A rise in body temperature often occurs for no particular cause.

  • Heavy sweating, especially at night.

  • Heavy weight loss without any effort.

  • Some might also experience itching throughout the body without any cause.

The doctors call the symptoms mentioned above B symptoms.

Burkitt lymphoma often starts or invades the abdomen and bowel, presenting with the following symptoms.

  • Bowel blockage (obstruction) and bleeding caused due to it.

  • Abdominal pain and discomfort.

  • Abdominal swelling due to the accumulation of fluid in the abdomen.

  • Back pain.

When Burkitt lymphoma affects the bone marrow, it can present with the following symptoms.

How to Diagnose Burkitt Lymphoma?

Burkitt lymphoma is a fast-growing type of cancer, and therefore prompt diagnosis is crucial for successful management.

  • Biopsy of the enlarged lymph nodes where a sample of the enlarged lymph node is seen under a microscope to confirm the diagnosis of Burkitt lymphoma is made.

  • Computed tomography (CT) scan to check for the spread and extent of the tumor.

  • Chest X-rays.

  • Assessment of the spinal fluid.

  • Bone marrow assessment.

  • Blood tests.

How to Treat Burkitt Lymphoma?

Burkitt lymphoma is a fast-growing type of non-Hodgkin's lymphoma and is fatal if left untreated. Therefore, the doctor starts the treatment as soon as the diagnosis is made to prolong the individual's lifespan.

  • Intravenous chemotherapy, which often requires a hospital stay, is one of the standard treatment methods done for Burkitt lymphoma.

  • Intrathecal chemotherapy is done where drugs are directly injected into the cerebrospinal fluid (CSF) when Burkitt lymphoma spreads to the brain and surrounding structures.

  • Some drugs are used in various combinations to treat Burkitt lymphoma.

  • Cytarabine.

  • Cyclophosphamide.

  • Etoposide.

  • Methotrexate.

  • Vincristine.

  • Radiation therapy.

  • Steroidal therapy.

  • In some cases, surgical removal of a part of the intestine might be done if obstruction or rupture occurs.


Burkitt lymphoma spreads fast to other vital organs of the body, which might be fatal. Early diagnosis and appropriate treatment can increase survival rates in 60% to 90% of children. It can give a complete cure in children, whereas adults cure rate is variable. Recent advances have shown an increased life span.

Frequently Asked Questions


How Long Can You Survive With Burkitt’s Lymphoma?

Burkitt’s lymphoma is fast-spreading cancer involving the lymphatic system of the body. The survival rate of Burkitt’s lymphoma is dependent on the stage of diagnosis. The chances of survival are around 90 % if diagnosed in stage 1 and stage 2. So, early diagnosis and management of Burkitt’s lymphoma is a key factor in deciding the overall survival rate of a patient.


Where Is Burkitt’s Lymphoma Found?

According to the World Health Organization (WHO), endemic Burkitt’s lymphoma is more common among children in Africa. Around 40 % of cases of Burkitt’s lymphoma are seen in the United States and western Europe.


What Are Warning Signs of Lymphoma?

Burkitt’s lymphoma is characterized by warning signs and symptoms like breathlessness, sudden weight loss, itchiness, and swelling of the face and neck.


What Area Is Most Commonly Affected by Burkitt’s Lymphoma?

Burkitt’s lymphoma commonly affects the jaws, gastro-intestinal tract (abdomen most frequently), and some types may involve the brain and spinal cord.


Is Burkitt’s Lymphoma Fatal?

Burkitt’s lymphoma is fast-spreading cancer and can involve other vital organs of the body which might be fatal.


Who Is Affected by Burkitt’s Lymphoma?

Burkitt's lymphoma can affect both adults and children but is more common in children between the ages of four years to seven years.


How Common Is Burkitt’s Lymphoma?

Burkitt's lymphoma is a rare but aggressive tumor that accounts for 1 % to 5 % of all non-Hodgkin's lymphoma.


How Can We Reduce the Risk of Getting Burkitt’s Lymphoma?

According to the research Burkitt's lymphoma is due to an alteration in the gene regulating the cell growth so there is nothing one can do to reduce the risk.


Can Burkitt Lymphoma Be Cured?

The cure of Burkitt’s lymphoma generally means the reduction or complete remission of the signs and symptoms associated with the disease.


What are the Survival Chances of Burkitt’s Lymphoma?

Patients with Burkitt's lymphoma who are diagnosed and treated early have shown reduction or complete remission of the symptoms associated with cancer thus increasing the chances of survival.


Is Burkitt Lymphoma Curable in Adults?

The chances of a cure for Burkitt’s lymphoma in adults vary. According to the current research, standard dose-intensive chemotherapy was proven to be effective in adults with Burkitt's lymphoma.


How Fast Does Burkitt Lymphoma Spread?

Burkitt's lymphoma is a rare but aggressive tumor and can involve the central nervous system, bowel, kidneys, jaw, and other organs.


What Is the Best Treatment for Burkitt’s Lymphoma?

The best treatment for Burkitt’s lymphoma is chemotherapy along with targeted immunotherapy for early remission of the associated symptoms.


Does Burkitt’s Lymphoma Return?

Yes, in a few cases the symptoms of Burkitt's lymphoma may recur after the treatment. It is further managed by secondary treatment.


Is Burkitt Lymphoma Painful?

Yes, Burkitt’s lymphoma is associated with mild to moderate abdominal pain. Patients with sporadic Burkitt lymphoma may experience abdominal pain or edema. Additionally, the illness may rapidly invade the brain and central nervous system, resulting in severe neurological symptoms like paralysis.


How Serious Is Burkitt Lymphoma?

Burkitt’s lymphoma is an aggressive and fast-growing cancer that can spread rapidly to multiple organs. It can be life-threatening if left untreated.


Why Is Burkitt Lymphoma Aggressive?

Burkitt’s lymphoma is aggressive due to its rapid spread and involvement of multiple organs like the brain and spinal cord through the lymphatic system within a short duration.


Is Burkitt’s Lymphoma Genetic?

The exact cause of Burkitt’s lymphoma is unknown. However, it may be caused by genetic translocation of the MYC (MYC Proto-oncogene, BHLH transcription factor) gene at chromosome number 8q24.


Is Burkitt’s Lymphoma Contagious?

Burkitt's lymphoma is supposed to be caused by Epstein Barr viral infection which can be contagious and can spread through body fluids like saliva.

Last reviewed at:
09 Mar 2023  -  4 min read




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