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Crimean-Congo Hemorrhagic Fever - Symptoms, Diagnosis, and Treatment

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Crimean-Congo Hemorrhagic Fever - Symptoms, Diagnosis, and Treatment

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Crimean-Congo hemorrhagic fever is a deadly zoonotic viral infection. Read about its transmission, symptoms, diagnosis, and treatment.

Medically reviewed by

Dr. Kaushal Bhavsar

Published At October 8, 2020
Reviewed AtSeptember 7, 2023

What Is Crimean Congo Hemorrhagic Fever?

Crimean-Congo hemorrhagic fever, otherwise called CCHF, is a zoonotic viral infection caused by the virus Nairovirus, which belongs to the Bunyaviridae family and is spread by ticks. It is transmitted in humans through direct contact with infected animal tissues in slaughterhouses. It is a hemorrhagic fever, meaning the symptoms include fever and bleeding disorders, which can progress to shock and death in many patients. Outbreaks of CCHF are a potential public health risk, as they can cause epidemics, and the fatality rate can reach up to 40 percent.

Outbreaks are more common in hospitals and healthcare facilities and have been reported in Africa, the Middle East, Asia, and the Balkans (southeastern Europe). As this infection was first described in 1944 in Crimea, it was named Crimean hemorrhagic fever. In 1969, scientists found that the virus that caused this infection was the same that caused an outbreak in Congo in the year 1956, so the disease was renamed as Crimean-Congo hemorrhagic fever (CCHF). No vaccine is available for humans and animals.

The spread of infection may be prevented by following precautionary measures while treating patients and administering prophylactic therapy for healthcare workers after exposure. It is also necessary to control the population of ticks through the use of pesticides.

How Is Crimean Congo Hemorrhagic Fever Transmitted?

CCHF virus can infect various wild and domestic animals, such as cattle, goats, sheep, etc. Most birds are resistant to this infection, but ostriches can get infected, and they are the cause of many human transmissions and outbreaks. An outbreak in South Africa recently was linked to an ostrich slaughterhouse. Animals that get infected, mostly by tick bites, do not show any symptoms. The CCHF virus remains in their blood for about one week after getting infected, which can transmit to other ticks that bite the infected animal.

The virus gets transmitted to humans through tick bites or contact with the blood and tissues of infected animals at the time and immediately after slaughter. Slaughterhouse workers, agricultural workers, and veterinarians are most susceptible. While tick is the major vector, secondary causes are commonly due to human-to-human transmission through contact with infected blood and bodily fluids. This commonly takes place among healthcare workers in hospitals. Improper sterilization of medical equipment and reusing needles can also result in hospital-acquired CCHF.

What Are the Signs and Symptoms of Crimean Congo Hemorrhagic Fever?

The incubation period of the CCHF virus varies based on the mode of transmission. After a tick bite, the incubation period is one to three days, which can be up to nine days. And that after contact with infected bodily fluids and tissues is five to six days, which can take up to 13 days. Patients usually develop sudden symptoms, such as:

  • Fever.
  • Muscle ache (myalgia).
  • Lightheadedness or dizziness.
  • Back pain.
  • Headaches.
  • Neck pain or stiffness.
  • Sore eyes.
  • Sensitivity to light (photophobia).
  • Nausea and vomiting.
  • Diarrhea.
  • Stomach pain.
  • Sore throat.

Later, patients develop:

  • Severe mood swings.
  • Confusion.
  • Sleepiness.
  • Depression.
  • Liver enlargement.
  • Rapid heartbeat (tachycardia).
  • Enlarged lymph nodes (lymphadenopathy).
  • Pinpoint red spots on the mucosa and skin (petechial rash).
  • The petechiae can result in bigger rashes called ecchymoses.

Patients may develop hepatitis, deterioration in kidney function, liver failure, and lung failure. The fatality rate ranges from 9 to 50 %, and severely ill patients usually die in the second week of illness. Recovered patients start to feel better after the ninth or tenth day of symptoms. The long-term effects have not been well studied. Recovery takes time.

Who Is at Risk of Getting Infected With the CCHF Virus?

People who work closely with animals, such as herders, slaughterhouse workers, veterinarians, and livestock workers, are at risk of CCHF. Healthcare providers are also at risk.

Crimean-Congo hemorrhagic fever is found in the Mediterranean, Eastern Europe (formerly the Soviet Union), northwestern China, Asia, the Middle East, southern Europe, Africa, and the Indian subcontinent.

How Is Crimean Congo Hemorrhagic Fever Diagnosed?

Various lab tests are available to diagnose the CCHF virus. The tests that can be done are:

  • Enzyme-linked immunosorbent assay (ELISA).
  • Reverse transcriptase-polymerase chain reaction (RT-PCR).
  • Virus isolation by cell culture.
  • Antigen detection.
  • Serum neutralization.

Even with severe infection, patients do not develop substantial antibody responses in the first few days of illness. So the diagnosis is made by the detection of virus or viral RNA in blood or tissue samples.

How Is Crimean Congo Hemorrhagic Fever Treated?

As there is no specific treatment, only supportive care is given to CCHF patients to help the body fight off the virus. The doctor will prescribe medicines to correct blood abnormalities and secondary infections. Oxygen support is provided if needed, and fluid balance is maintained. After doctors found the virus to be sensitive to the antiviral medicine Ribavirin, it is being used to treat CCHF patients.

Can Crimean Congo Hemorrhagic Fever Be Prevented?

No vaccine is available against CCHF for both animals and humans. Sticking to strict precautionary measures is the best way to prevent this infection. The ways for reducing the risk of infection include the following:

1. Reducing the Risk of CCHF in Animals:

As animals do not show any symptoms even after getting infected, it is very difficult to identify and prevent CCHF in animals and to stop the tick-animal-tick cycle. Acaricides, chemicals used to kill ticks, can be used in livestock facilities to keep animals tick-free. In a recent outbreak in an ostrich slaughterhouse in South Africa, ostriches were held tick-free for 14 days in quarantine before slaughtering them. This drastically reduced animal-to-human transmission.

2. Reducing the Risk of CCHF in Humans:

Educating people about the way this virus spreads and what they can do to stop it is crucial.

CCHF virus transmission can be prevented from animals to humans by:

  • Wearing long pants and trousers and other protective clothing while handling livestock.
  • Preferably, wear light-colored clothes, as ticks can be easily detected.
  • One can use Acaricides on clothes to kill ticks.
  • If one finds ticks on the skin or clothes, remove them carefully.
  • Use pesticides in stables and barns.
  • Wear gloves while handling animals or their carcasses.
  • Before slaughtering an animal, keep them in quarantine for 14 days or treat them with chemicals that kill ticks.

To prevent human-to-human transmission take the following steps:

  • Do not come in direct contact with CCHF patients.
  • If caring for CCHF patients, wear gloves and protective equipment.
  • Do not forget to wash hands regularly after caring for ill people.
  • In hospitals, healthcare workers should implement infection control precautions, such as proper hand hygiene, the use of PPE (personal protective equipment), and safe injection practices.

Conclusion

Crimean-Congo hemorrhagic fever is a viral infection transmitted in humans through direct contact with infected animal tissues. No vaccine is available against CCHF for both animals and humans. But, the spread of this infection can be prevented by following precautionary measures and taking steps to control the population of ticks.

Frequently Asked Questions

1.

How Is Crimean Congo Fever Transmitted?

Crimean Congo hemorrhagic fever is transmitted to humans through infected ticks or animals. Human-to-human transmission occurs through contact with infected body fluids or blood.

2.

How Do People Survive Hemorrhagic Fever?

Supportive symptomatic treatment is the primary approach in managing Crimean Congo hemorrhagic fever. It is essential to maintain fluid balance and oxygen saturation. Ribavirin, an antiviral drug, is found to be effective against the virus.

3.

How Long Does Crimean-Congo Hemorrhagic Fever Last?

The incubation period following a tick bite is one to three days, and after coming in contact with infected blood or tissue, it is five to six days with a maximum of thirteen days. Patients usually recover completely by the ninth or tenth day of symptoms.

4.

How Is Hemorrhagic Fever Prevented?

Crimean Congo hemorrhagic fever can be prevented by reducing the risk of animal-to-human and human-to-human transmission. Avoid or minimize contact with an infected person, avoid tick exposure by using insect repellent, and wear protective clothing while handling farm animals. In addition, ensuring proper hand hygiene can significantly reduce the risk of disease transmission.

5.

How Is Hemorrhagic Fever Contracted?

Crimean Congo, hemorrhagic fever virus can easily infect domestic and wild animals. They usually get infected by the tick bite, thus serving as a host for the virus to multiply. Direct contact with the animals or their body fluid and tissue can result in the transmission of the disease to humans. Human-to-human transmission occurs via contact with body fluids and blood.

6.

Who Are the People at Risk of Getting Congo Fever?

Individuals who work closely with livestock or animals, such as farmers, slaughterhouse workers, herders, and veterinarians. Even healthcare workers are also at risk as they can be exposed to the infected body fluids of the patients.

7.

How Can We Prevent Crimean-Congo Hemorrhagic Fever?

People working with livestock and animals are advised to use insect repellent to ward off ticks. Additionally, wearing protective clothing, such as gloves, while handling livestock can prove beneficial.

8.

Is Congo Virus Airborne?

Crimean Congo hemorrhagic fever is a tick-borne disease transmitted by the bite of infected ticks. However, a small number of cases have been reported to be nosocomial or airborne infections.

9.

Is Hemorrhagic Fevers Viral or Bacterial?

Crimean Congo hemorrhagic fever is a zoonotic viral infection caused by Nairovirus and is spread by ticks.

10.

When Did Hemorrhagic Fever Start?

Crimean Congo hemorrhagic fever was first reported by Soviet soldiers in Crimea in 1944 and was hence named Crimean fever. Subsequently, in 1969 it was identified that the same pathogen was responsible for Congo hemorrhagic fever. Thus, the disease was called Crimean Congo hemorrhagic fever.

11.

Is Crimean-Congo Hemorrhagic Fever Zoonotic?

Crimean Congo hemorrhagic fever is a zoonotic viral infection transmitted to humans via tick bites. The animals serve as a reservoir or host for these viruses to multiply, later spreading the disease.

12.

Is Crimean Congo Hemorrhagic Fever Fatal?

The fatality rate varies from 9 % to 50 %. Patients can develop complications such as hepatitis, kidney, liver, or lung failure. It may prove fatal if not diagnosed and treated promptly.
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Dr. Kaushal Bhavsar
Dr. Kaushal Bhavsar

Pulmonology (Asthma Doctors)

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