"Seronegative rheumatoid arthritis is an autoimmune disease in which a person has rheumatoid arthritis without having anti-cyclic citrullinated peptide (anti-CCP) antibodies or rheumatoid factor in their blood. People with seronegative rheumatoid arthritis may develop antibodies later in life. The symptoms of seronegative rheumatoid arthritis include tenderness, swelling, and redness in the joints, stiffness, especially in the hands, knees, ankles, hips, and elbows, stiffness in the morning that lasts for longer than 30 minutes, and persistent inflammation. Nonsteroidal and anti-inflammatory drugs (NSAIDs) and steroids help relieve these symptoms. "
Impact of Seronegative Status in Rheumatoid Arthritis - A Discussion
A person who tests negative for rheumatoid factor (RF) and cyclic citrullinated peptide (CCP) antibodies has seronegative rheumatoid arthritis.
